Literature DB >> 384999

Localization of the heparin-releasable lipase in situ in the rat liver.

T Kuusi, E A Nikklä, I Virtanen, P K Kinnunen.   

Abstract

Immunofluorescence and immuno-electron microscopy were used for the localization of the heparin-releasable lipase in situ in the rat liver. The lipase is located exclusively on the liver endothelial cells. No labelling could be detected on the parenchymal of Kupffer cells, or in the livers of heparin-pretreated animals. The physiological significance of the endothelial localization of the hepatic lipase is discussed.

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Year:  1979        PMID： 384999      PMCID： PMC1161147          DOI： 10.1042/bj1810245

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  15 in total

1.  In vivo uptake of human and rat low density and high density lipoprotein by parenchymal and nonparenchymal cells from rat liver.

Authors:  T J van Berkel; A van Tol
Journal:  Biochim Biophys Acta       Date:  1978-08-25

2.  Comparison of the triglyceride lipase of liver, adipose tissue, and postheparin plasma.

Authors:  J C LaRosa; R I Levy; H G Windmueller; D S Fredrickson
Journal:  J Lipid Res       Date:  1972-05       Impact factor: 5.922

3.  Metabolism of iodinated very low density lipoprotein in the rat. Autoradiographic localization in the liver.

Authors:  O Stein; D Rachmilewitz; L Sanger; S Eisenberg; Y Stein
Journal:  Biochim Biophys Acta       Date:  1974-08-22

4.  Hydrolysis of monoacylglycerol in lipoprotein remnants catalyzed by the liver plasma membrane monoacylglycerol acyltransferase.

Authors:  M R El-Maghrabi; M Waite; L L Rudel; P Sisson
Journal:  J Biol Chem       Date:  1978-02-10       Impact factor: 5.157

5.  Solubilization by heparin of the phospholipase A1 from the plasma membranes of rat liver.

Authors:  M Waite; P Sisson
Journal:  J Biol Chem       Date:  1973-10-25       Impact factor: 5.157

6.  Characterization, subcellular localization, and partial purification of a heparin-released triglyceride lipase from rat liver.

Authors:  G Assmann; R M Krauss; D S Fredrickson; R I Levy
Journal:  J Biol Chem       Date:  1973-03-25       Impact factor: 5.157

7.  A simple purification procedure for rat hepatic lipase.

Authors:  T Kuusi; P K Kinnunen; C Ehnholm; E A Nikkilä
Journal:  FEBS Lett       Date:  1979-02-15       Impact factor: 4.124

8.  Binding of liver lipase to parenchymal and non-parenchymal rat liver cells.

Authors:  H Jansen; T J van Berkel; W C Hülsmann
Journal:  Biochem Biophys Res Commun       Date:  1978-11-14       Impact factor: 3.575

9.  High density lipoprotein and low density lipoprotein catabolism by human liver and parenchymal and non-parenchymal cells from rat liver.

Authors:  T J Van Berkel; J F Koster; W C Hülsmann
Journal:  Biochim Biophys Acta       Date:  1977-03-25

10.  Rate constants for the uptake of cholesterol from various intestinal and serum lipoprotein fractions by the liver of the rat in vivo.

Authors:  J M Andersen; F O Nervi; J M Dietschy
Journal:  Biochim Biophys Acta       Date:  1977-02-23
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  16 in total

1.  Secretion of hepatic lipase by perfused liver and isolated hepatocytes.

Authors:  X Galan; M Q Robert; M Llobera; I Ramírez
Journal:  Lipids       Date:  2000-09       Impact factor: 1.880

2.  The preferential uptake of very-low-density lipoprotein cholesteryl ester by rat liver in vivo.

Authors:  J C Holder; V A Zammit; D S Robinson
Journal:  Biochem J       Date:  1990-12-15       Impact factor: 3.857

Review 3.  Scavenger functions of the liver endothelial cell.

Authors:  B Smedsrød; H Pertoft; S Gustafson; T C Laurent
Journal:  Biochem J       Date:  1990-03-01       Impact factor: 3.857

4.  One year study of effects of an oestrogen-dominant oral contraceptive on serum high-density lipoprotein cholesterol, apolipoproteins A-I and A-II and hepatic microsomal function.

Authors:  P V Luoma; J E Heikkinen; C Ehnholm; P R Ylöstalo
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

5.  Evidence that cholesteryl ester hydrolase and triglyceride lipase are different enzymes in rat liver.

Authors:  J J Chen; V Rothman; S Margolis
Journal:  Lipids       Date:  1986-08       Impact factor: 1.880

6.  Lipoprotein lipase-mediated uptake and degradation of low density lipoproteins by fibroblasts and macrophages.

Authors:  S C Rumsey; J C Obunike; Y Arad; R J Deckelbaum; I J Goldberg
Journal:  J Clin Invest       Date:  1992-10       Impact factor: 14.808

7.  Lipoprotein metabolism during acute inhibition of hepatic triglyceride lipase in the cynomolgus monkey.

Authors:  I J Goldberg; N A Le; J R Paterniti; H N Ginsberg; F T Lindgren; W V Brown
Journal:  J Clin Invest       Date:  1982-12       Impact factor: 14.808

8.  Rat liver contains a limited number of binding sites for hepatic lipase.

Authors:  K Schoonderwoerd; A J Verhoeven; H Jansen
Journal:  Biochem J       Date:  1994-09-15       Impact factor: 3.857

9.  Hydrolysis of neutral lipid substrates by rat hepatic lipase.

Authors:  R W Wilcox; T Thuren; P Sisson; G L Kucera; M Waite
Journal:  Lipids       Date:  1991-04       Impact factor: 1.880

10.  The removal of partially metabolized very-low-density lipoproteins by the perfused rat liver.

Authors:  B S Suri; M E Targ; D S Robinson
Journal:  Biochem J       Date:  1981-06-15       Impact factor: 3.857
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