Literature DB >> 3848491

Substituted 2-pyrones, 2-pyridones, and other congeners of elasnin as potential agents for the treatment of chronic obstructive lung diseases.

W C Groutas, M A Stanga, M J Brubaker, T L Huang, M K Moi, R T Carroll.   

Abstract

Several congeners of elasnin (I) have been synthesized and shown to inhibit human leukocyte elastase (HLE). The C-3 alkyl substituted 2-pyrones 11 and 12 were found to be the most effective inhibitors of the enzyme. These compounds are highly specific in their inhibitory activity.

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Year:  1985        PMID： 3848491     DOI： 10.1021/jm00146a023

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  4 in total

1.  An efficient tandem approach for the synthesis of functionalized 2-pyridone-3-carboxylic acids using three-component reaction in aqueous media.

Authors:  Saber Mehrparvar; Saeed Balalaie; Mahnaz Rabbanizadeh; Elmira Ghabraie; Frank Rominger
Journal:  Mol Divers       Date:  2014-05-04       Impact factor: 2.943

2.  Increased expression of Saccharomyces cerevisiae translation elongation factor 1 alpha bypasses the lethality of a TEF5 null allele encoding elongation factor 1 beta.

Authors:  T G Kinzy; J L Woolford
Journal:  Genetics       Date:  1995-10       Impact factor: 4.562

3.  Singlet Oxygen Formation vs Photodissociation for Light-Responsive Protic Ruthenium Anticancer Compounds: The Oxygenated Substituent Determines Which Pathway Dominates.

Authors:  Fengrui Qu; Robert W Lamb; Colin G Cameron; Seungjo Park; Olaitan Oladipupo; Jessica L Gray; Yifei Xu; Houston D Cole; Marco Bonizzoni; Yonghyun Kim; Sherri A McFarland; Charles Edwin Webster; Elizabeth T Papish
Journal:  Inorg Chem       Date:  2021-02-03       Impact factor: 5.165

4.  Elasnin Effectively Eradicates Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus Biofilms.

Authors:  Jordy Evan Sulaiman; Lexin Long; Pei-Yuan Qian; Henry Lam
Journal:  Microbiol Spectr       Date:  2022-02-23
  4 in total

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