Literature DB >> 3846459

Protein C antigen in prothrombin complex concentrates: content, recovery and half life.

H Riess, T Binsack, E Hiller.   

Abstract

Protein C, a potent anticoagulant, has been detected in large amounts in some prothrombin complex concentrates (PCC). We extended these findings to eight PCC commercially available in West Germany detecting 0.82 to 1.92 plasma equivalent units of protein C antigen (PC:Ag) per unit factor IX. Infusion of PCC in four patients on stable oral anticoagulation resulted in a recovery of 58.6 +/- 10.9%. Estimated from the decrease in plasma levels of PC:Ag half life was 7.9 +/- 0.6 h.

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Year:  1985        PMID： 3846459     DOI： 10.1007/bf00319757

Source DB:  PubMed          Journal:  Blut        ISSN： 0006-5242


  16 in total

1.  A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization.

Authors:  J Stenflo
Journal:  J Biol Chem       Date:  1976-01-25       Impact factor: 5.157

2.  The preparation and clinical use of a new concentrate containing factor IX, prothrombin and factor X and of a separate concentrate containing factor VII.

Authors:  G W Dike; E Bidwell; C R Rizza
Journal:  Br J Haematol       Date:  1972-04       Impact factor: 6.998

3.  Anticoagulant properties of bovine plasma protein C following activation by thrombin.

Authors:  W Kisiel; W M Canfield; L H Ericsson; E W Davie
Journal:  Biochemistry       Date:  1977-12-27       Impact factor: 3.162

4.  Protein concentrates for therapeutic use.

Authors:  R M Bertina; A W Broekmans
Journal:  Lancet       Date:  1982-12-11       Impact factor: 79.321

5.  Decrease in protein C antigen and formation of an abnormal protein soon after starting oral anticoagulant therapy.

Authors:  S Viganò; P M Mannucci; S Solinas; B Bottasso; G Mariani
Journal:  Br J Haematol       Date:  1984-06       Impact factor: 6.998

6.  The fibrinolytic system in patients with congenital protein C deficiency.

Authors:  J Conard; M H Horellou; A C Teger-Nilsson; R M Bertina; M Samama
Journal:  Thromb Res       Date:  1984-11-15       Impact factor: 3.944

7.  Human plasma protein C: isolation, characterization, and mechanism of activation by alpha-thrombin.

Authors:  W Kisiel
Journal:  J Clin Invest       Date:  1979-09       Impact factor: 14.808

8.  Generation of fibrinolytic activity by infusion of activated protein C into dogs.

Authors:  P C Comp; C T Esmon
Journal:  J Clin Invest       Date:  1981-11       Impact factor: 14.808

9.  Protein C, an antithrombotic protein, is reduced in hospitalized patients with intravascular coagulation.

Authors:  J H Griffin; D F Mosher; T S Zimmerman; A J Kleiss
Journal:  Blood       Date:  1982-07       Impact factor: 22.113

10.  Deficiency of protein C in congenital thrombotic disease.

Authors:  J H Griffin; B Evatt; T S Zimmerman; A J Kleiss; C Wideman
Journal:  J Clin Invest       Date:  1981-11       Impact factor: 14.808
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  2 in total

1.  A Joint Model for Vitamin K-Dependent Clotting Factors and Anticoagulation Proteins.

Authors:  Qing Xi Ooi; Daniel F B Wright; R Campbell Tait; Geoffrey K Isbister; Stephen B Duffull
Journal:  Clin Pharmacokinet       Date:  2017-12       Impact factor: 6.447

2.  Evaluation of a new protein-C concentrate and comparison of protein-C assays in a child with congenital protein-C deficiency.

Authors:  K Auberger
Journal:  Ann Hematol       Date:  1992-03       Impact factor: 3.673
  2 in total

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