Literature DB >> 3844977

Localization of an anti-CEA monoclonal antibody in colo-rectal carcinoma xenografts.

M V Pimm, N C Armitage, A C Perkins, W Smith, R W Baldwin.   

Abstract

A mouse monoclonal anti-CEA antibody (11.285.14) has been examined for tumour localization potential by assessing its distribution in immunodeprived mice with xenografts of human colon carcinoma cell lines HCT-8, HRT-18, HT-29, and LS174T and a xenograft (HRVB) established from a primary rectal carcinoma. With four carcinomas (HCT-8, HT-29, LS174T, and HRVB) preferential tumour localization of 125I anti-CEA was seen. Compared with 131I normal IgG1 localization indices of up to 4.4:1 were achieved. Up to 10% of the injected dose of 125I anti-CEA was present/g of tumour tissue and with the largest xenografts examined (3-4 g) up to 40% of the total body reactivity was localized in tumour tissue. The tumour localization of 131I labelled antibody was visualized by external gamma camera imaging. Overall antibody localization correlated with the CEA content of the xenografts and the fourth colon carcinoma xenograft (HRT-18) and an osteogenic sarcoma xenograft (791T), both with very low CEA levels, showed no localization of the monoclonal antibody.

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Year:  1985        PMID： 3844977     DOI： 10.1007/bf00199305

Source DB:  PubMed          Journal:  Cancer Immunol Immunother        ISSN： 0340-7004            Impact factor:   6.968


  18 in total

1.  Use of monoclonal antibodies for the histopathological diagnosis of human malignancy.

Authors:  K C Gatter; Z Abdulaziz; P Beverley; J R Corvalan; C Ford; E B Lane; M Mota; J R Nash; K Pulford; H Stein; J Taylor-Papadimitriou; C Woodhouse; D Y Mason
Journal:  J Clin Pathol       Date:  1982-11       Impact factor: 3.411

2.  In vivo localization of anti-osteogenic sarcoma 791T monoclonal antibody in osteogenic sarcoma xenografts.

Authors:  M V Pimm; M J Embleton; A C Perkins; M R Price; R A Robins; G R Robinson; R W Baldwin
Journal:  Int J Cancer       Date:  1982-07-15       Impact factor: 7.396

3.  Imaging of human melanoma xenografts in nude mice with a radiolabeled monoclonal antibody.

Authors:  T Ghose; S Ferrone; K Imai; S T Norvell; S J Luner; R H Martin; A H Blair
Journal:  J Natl Cancer Inst       Date:  1982-10       Impact factor: 13.506

4.  Experimental studies of tumor radioimmunodetection using antibody mixtures against carcinoembryonic antigen (CEA) and colon-specific antigen-p (CSAp).

Authors:  S A Gaffar; K D Pant; D Shochat; S J Bennett; D M Goldenberg
Journal:  Int J Cancer       Date:  1981-01-15       Impact factor: 7.396

5.  Imaging of melanoma with L-131-labeled monoclonal antibodies.

Authors:  S M Larson; J P Brown; P W Wright; J A Carrasquillo; I Hellström; K E Hellström
Journal:  J Nucl Med       Date:  1983-02       Impact factor: 10.057

6.  Tumor localization of CEA-containing human tumors in nude mice by means of monoclonal anti-CEA antibodies.

Authors:  A Hedin; B Wahren; S Hammarström
Journal:  Int J Cancer       Date:  1982-11-15       Impact factor: 7.396

7.  Immunological heterogeneity of carcinoembryonic antigen: antigenic determinants on carcinoembryonic antigen distinguished by monoclonal antibodies.

Authors:  F J Primus; K D Newell; A Blue; D M Goldenberg
Journal:  Cancer Res       Date:  1983-02       Impact factor: 12.701

8.  Binding of five monoclonal anti-CEA antibodies with different epitope specificities to various carcinoma tissues.

Authors:  C Wagener; P Petzold; W Köhler; V Totović
Journal:  Int J Cancer       Date:  1984-04-15       Impact factor: 7.396

9.  Improved immune-suppression techniques for the exongrafting of human tumours.

Authors:  G G Steel; V D Courtenay; A Y Rostom
Journal:  Br J Cancer       Date:  1978-02       Impact factor: 7.640

10.  Localization of human tumour xenografts after i.v. administration of radiolabeled monoclonal antibodies.

Authors:  V Moshakis; R A McIlhinney; D Raghavan; A M Neville
Journal:  Br J Cancer       Date:  1981-07       Impact factor: 7.640
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  14 in total

1.  Drug localisation and growth inhibition studies of vindesine-monoclonal anti-CEA conjugates in a human tumour xenograft.

Authors:  G F Rowland; R G Simmonds; V A Gore; C H Marsden; W Smith
Journal:  Cancer Immunol Immunother       Date:  1986       Impact factor: 6.968

2.  Capture of recombinant ricin A chain by a bispecific anti-RTA:anti-CEA monoclonal antibody pre-targeted to a human gastric carcinoma xenograft in nude mice.

Authors:  M V Pimm; R A Robins; R W Baldwin
Journal:  J Cancer Res Clin Oncol       Date:  1992       Impact factor: 4.553

3.  Human parathyroid antigen: characterization and localization with monoclonal antibodies.

Authors:  W G Cance; S A Wells; W G Dilley; M J Welch; F L Otsuka; J M Davie
Journal:  Proc Natl Acad Sci U S A       Date:  1986-08       Impact factor: 11.205

Review 4.  Antibody-mediated targeting in the treatment and diagnosis of cancer: an overview.

Authors:  C H Ford; A G Casson
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

5.  The detection of virally induced tumors by 131I- and 125I-labeled syngeneic monoclonal antibodies.

Authors:  D Berends; J L van Gaalen; E H Rhijnsburger; N J de Both; W Breeman; W H Bakker; P Kooy
Journal:  Cancer Immunol Immunother       Date:  1988       Impact factor: 6.968

6.  Diverse characteristics of 111In labelled anti-CEA monoclonal antibodies for tumour immunoscintigraphy: radiolabelling, biodistribution and imaging studies in mice with human tumour xenografts.

Authors:  M V Pimm; A C Perkins; R W Baldwin
Journal:  Eur J Nucl Med       Date:  1987

7.  Comparative imaging and biodistribution studies with an anti-CEA monoclonal antibody and its F(ab)2 and Fab fragments in mice with colon carcinoma xenografts.

Authors:  S M Andrew; M V Pimm; A C Perkins; R W Baldwin
Journal:  Eur J Nucl Med       Date:  1986

8.  In vivo studies on the uptake of radiolabelled antibodies by colorectal and gastric carcinoma xenografts.

Authors:  F Macdonald; M C Crowson; W H Allum; P Life; J W Fielding
Journal:  Cancer Immunol Immunother       Date:  1986       Impact factor: 6.968

9.  Effect of dose escalation of a monoclonal anti-CEA IgG on tumour localisation and tissue distribution in nude mice xenografted with human colon carcinoma.

Authors:  G T Rogers; R B Pedley; J Boden; P J Harwood; K D Bagshawe
Journal:  Cancer Immunol Immunother       Date:  1986       Impact factor: 6.968

10.  Construction and characterisation of a hybrid-hybrid monoclonal antibody recognising both carcinoembryonic antigen (CEA) and vinca alkaloids.

Authors:  J R Corvalan; W Smith
Journal:  Cancer Immunol Immunother       Date:  1987       Impact factor: 6.968
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