Literature DB >> 3843217

Clinical experience with clobazam: a new 1,5 benzodiazepine in the treatment of refractory epilepsy.

F J Vajda, P F Bladin, B J Parsons.   

Abstract

A benzodiazepine drug, clobazam, was evaluated in 14 refractory epileptic patients, nine of whom received the drug double-blind. Ten patients have been given clobazam long enough to assess results. Four showed marked benefit, four failed to respond and two showed a transient benefit which was maintained by dose changes of both clobazam and clonazepam. Side effects were minimal; doses ranged from 15 to 60 mg per day. Clobazam may have place in the treatment of the Lennox Gastaut syndrome and other types of refractory seizures.

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Year:  1985        PMID: 3843217

Source DB:  PubMed          Journal:  Clin Exp Neurol        ISSN: 0196-6383


  8 in total

Review 1.  Clobazam.

Authors:  Yu-tze Ng; Stephen D Collins
Journal:  Neurotherapeutics       Date:  2007-01       Impact factor: 7.620

Review 2.  Clobazam add-on therapy for drug-resistant epilepsy.

Authors:  Rebecca Bresnahan; Kirsty J Martin-McGill; John Williamson; Benedict D Michael; Anthony G Marson
Journal:  Cochrane Database Syst Rev       Date:  2019-10-22

Review 3.  Treatment of Lennox-Gastaut syndrome.

Authors:  Eleanor C Hancock; J Helen Cross
Journal:  Cochrane Database Syst Rev       Date:  2013-02-28

4.  Clobazam as an adjunctive therapy in treating seizures associated with Lennox-Gastaut syndrome.

Authors:  Jennifer T Leahy; Catherine J Chu-Shore; Janet L Fisher
Journal:  Neuropsychiatr Dis Treat       Date:  2011-11-11       Impact factor: 2.570

5.  Anti-seizure medications for Lennox-Gastaut syndrome.

Authors:  Francesco Brigo; Katherine Jones; Christin Eltze; Sara Matricardi
Journal:  Cochrane Database Syst Rev       Date:  2021-04-07

Review 6.  Clobazam and Its Use in Epilepsy.

Authors:  Marius Pernea; Alastair G Sutcliffe
Journal:  Pediatr Rep       Date:  2016-06-15

7.  Treatment of Lennox-Gastaut syndrome: overview and recent findings.

Authors:  Kenou van Rijckevorsel
Journal:  Neuropsychiatr Dis Treat       Date:  2008-12       Impact factor: 2.570

Review 8.  Clobazam monotherapy for focal or generalized seizures.

Authors:  Ravindra Arya; Nisha Giridharan; Vidhu Anand; Sushil K Garg
Journal:  Cochrane Database Syst Rev       Date:  2018-07-11
  8 in total

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