Literature DB >> 3841514

Intrathecal morphine slows gastrointestinal transit in rats.

R J Koslo, J L Vaught, A Cowan, D E Gmerek, F Porreca.   

Abstract

Intrathecal (i.th.) (by direct lumbar puncture) and intraperitoneal (i.p.) administration of morphine (30-100 micrograms/rat) caused a dose-related inhibition of gastrointestinal transit in the rat. Pretreatment with i.th. naloxone (5 micrograms at -5 min) reversed the effects of i.th., but not i.p., morphine. These results suggest that the spinal cord appears to be a target site for the inhibitory effects of morphine on gastrointestinal transit in the rat.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 3841514     DOI： 10.1016/0014-2999(85)90303-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  2 in total

1.  Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives as peripheral selective μ opioid receptor Agents.

Authors:  Yunyun Yuan; Orgil Elbegdorj; Jianyang Chen; Shashidhar K Akubathini; Feng Zhang; David L Stevens; Irina O Beletskaya; Krista L Scoggins; Zhenxian Zhang; Phillip M Gerk; Dana E Selley; Hamid I Akbarali; William L Dewey; Yan Zhang
Journal:  J Med Chem       Date:  2012-11-09       Impact factor: 7.446

2.  The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activity.

Authors:  Scott R Armstrong; Christina B Campbell; Carrie L Richardson; Ross G Vickery; Pamela R Tsuruda; Daniel D Long; Sharath S Hegde; David T Beattie
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-03-13       Impact factor: 3.000
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.