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Literature DB >> 3840818

Colloid droplet accumulation precedes the enhancement of 6-keto-PGF 1 alpha release from the thyrotropin-stimulated thyroid gland.

M Pawlikowski, A Lewinski, J Kunert-Radek, E Karasek, Z Mroz-Wasilewska, B Muszynska.

Abstract

Influence of thyrotropin (TSH) on colloid droplet formation in thyroid follicular cells and on release of a stable prostacyclin metabolite, 6-keto-prostaglandin 1 alpha (6-keto-PGF 1 alpha) from the thyroid has been studied in rats. Maximal accumulation of colloid droplets preceded the enhancement of the 6-keto-PGF 1 alpha release. Such a time sequence speaks against the possibility of prostacyclin involvement in the thyroid secretory response to TSH.

Entities: Chemical Species

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Year: 1985 PMID： 3840818 DOI： 10.1007/bf03348499

Source DB: PubMed Journal: J Endocrinol Invest ISSN： 0391-4097 Impact factor: 4.256

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References

13 in total

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Authors: J M Boeynaems; J Van Sande; J E Dumont
Journal: Biochem Pharmacol Date: 1975-07-15 Impact factor: 5.858

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Authors: C Willems; P A Rocmans; J E Dumont
Journal: Biochim Biophys Acta Date: 1970-11-24

Colloid droplet accumulation precedes the enhancement of 6-keto-PGF 1 alpha release from the thyrotropin-stimulated thyroid gland.

1. Blocking of dog thyroid secretion in vitro by inhibitors of prostaglandin synthesis.

2. Stimulation in vitro by thyrotropin, cyclic 3',5'-AMP, dibutyryl cylclic 3',5'-AMP and prostaglandin E1, of secretion by dog thyroid slices.

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8. The effect of elevated doses of thyrotropin on mouse thyroid.

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