Literature DB >> 3840792

Lactoquinomycin, a novel anticancer antibiotic. II. Physico-chemical properties and structure assignment.

T Okabe, K Nomoto, H Funabashi, S Okuda, H Suzuki, N Tanaka.   

Abstract

Lactoquinomycin, a new antibiotic, C24H27NO8, mp 151 approximately 159 degrees C (dec), FAB-MS: m/z 458 (MH+), is a basic substance, showing UV lambda MeOHmax (epsilon) 215 (37,600), 254 (10,700) and 432 nm (4,760), and IR nu CHCl3max 1790 (gamma-lactone), 1665 and 1650 (quinone) cm-1. The structure of lactoquinomycin has been elucidated by 1H NMR and ORD in comparison with those of kalafungin.

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Year:  1985        PMID： 3840792     DOI： 10.7164/antibiotics.38.1333

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  7 in total

1.  Xiakemycin A, a novel pyranonaphthoquinone antibiotic, produced by the Streptomyces sp. CC8-201 from the soil of a karst cave.

Authors:  Zhong-ke Jiang; Lin Guo; Chuan Chen; Shao-wei Liu; Lin Zhang; Su-juan Dai; Qi-yang He; Xue-fu You; Xin-xin Hu; Li Tuo; Wei Jiang; Cheng-hang Sun
Journal:  J Antibiot (Tokyo)       Date:  2015-06-24       Impact factor: 2.649

Review 2.  A comprehensive review of glycosylated bacterial natural products.

Authors:  Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal:  Chem Soc Rev       Date:  2015-11-07       Impact factor: 54.564

3.  Expression, Crystallization and Preliminary X-ray Diffraction Analyses of Med-ORF10 in the Biosynthetic Pathway of an Antitumor Antibiotic Medermycin.

Authors:  Yanli Liu; Shasha Liu; Tingting Yang; Xiaoxia Guo; Yali Jiang; Kashif Rafiq Zahid; Ke Liu; Jinlin Liu; Jihong Yang; Haobin Zhao; Yi Yang; Aiying Li; Chao Qi
Journal:  Protein J       Date:  2015-12       Impact factor: 2.371

4.  Vertirhodins A-F, C-Linked Pyrrolidine-Iminosugar-Containing Pyranonaphthoquinones from Streptomyces sp. B15-008.

Authors:  Jiadong Sun; Gengxiang Zhao; Robert D O'Connor; Jack R Davison; Carole A Bewley
Journal:  Org Lett       Date:  2021-01-14       Impact factor: 6.072

5.  Cytocidal activity of a synthetic isoprenoid, N-solanesyl-N,N'-bis(3,4-dimethoxybenzyl)ethylenediamine, and its potentiation of antitumor drugs against multidrug-resistant and sensitive cells in vitro.

Authors:  H Suzuki; A Tomida; T Nishimura
Journal:  Jpn J Cancer Res       Date:  1990-03

6.  Antibacterial Activity and Mode of Action of Lactoquinomycin A from Streptomyces bacillaris.

Authors:  Beomkoo Chung; Oh-Seok Kwon; Jongheon Shin; Ki-Bong Oh
Journal:  Mar Drugs       Date:  2020-12-24       Impact factor: 5.118

7.  Chimeric natural products derived from medermycin and the nature-inspired construction of their polycyclic skeletons.

Authors:  Shupeng Yin; Zhi Liu; Jingjing Shen; Yuwei Xia; Weihong Wang; Pengyan Gui; Qian Jia; Konthorn Kachanuban; Weiming Zhu; Peng Fu
Journal:  Nat Commun       Date:  2022-09-02       Impact factor: 17.694
  7 in total

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