Literature DB >> 3840715

Muscarinic cholinergic receptors in the human spinal cord: differential localization of [3H]pirenzepine and [3H]quinuclidinylbenzilate binding sites.

J W Villiger, R L Faull.   

Abstract

The localization of muscarinic cholinergic receptor subtypes was studied in the human spinal cord using in vitro labelling of cryostat sections with [3H]quinuclidinylbenzilate (QNB) and [3H]pirenzepine (PZ) followed by autoradiography. The highest densities of [3H]QNB binding were localized in laminae II (substantia gelatinosa) and IX (motor neurons); in contrast, the highest density of [3H]PZ binding was localized to lamina II where the binding density was 22-32% higher than in lamina IX. These results suggest that the M1 and M2 muscarinic cholinergic receptor subtypes may be differentially localized in sensory and motor regions of the human spinal cord.

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Year:  1985        PMID： 3840715     DOI： 10.1016/0006-8993(85)90854-6

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  12 in total

1.  Dynamic regulation of glycinergic input to spinal dorsal horn neurones by muscarinic receptor subtypes in rats.

Authors:  Xiu-Li Wang; Hong-Mei Zhang; De-Pei Li; Shao-Rui Chen; Hui-Lin Pan
Journal:  J Physiol       Date:  2006-01-12       Impact factor: 5.182

2.  Muscarinic facilitation of GABA release in substantia gelatinosa of the rat spinal dorsal horn.

Authors:  H Baba; T Kohno; M Okamoto; P A Goldstein; K Shimoji; M Yoshimura
Journal:  J Physiol       Date:  1998-04-01       Impact factor: 5.182

3.  Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice.

Authors:  Shao-Rui Chen; Hong Chen; Wei-Xiu Yuan; Jürgen Wess; Hui-Lin Pan
Journal:  J Biol Chem       Date:  2014-04-02       Impact factor: 5.157

Review 4.  Synaptic control of motoneuronal excitability.

Authors:  J C Rekling; G D Funk; D A Bayliss; X W Dong; J L Feldman
Journal:  Physiol Rev       Date:  2000-04       Impact factor: 37.312

5.  Dynamic control of glutamatergic synaptic input in the spinal cord by muscarinic receptor subtypes defined using knockout mice.

Authors:  Shao-Rui Chen; Hong Chen; Wei-Xiu Yuan; Jürgen Wess; Hui-Lin Pan
Journal:  J Biol Chem       Date:  2010-10-12       Impact factor: 5.157

6.  The effects of cholinoceptor agonists and antagonists on C-fibre evoked responses in the substantia gelatinosa of neonatal rat spinal cord slices.

Authors:  L Bleazard; R Morris
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

7.  Signaling mechanisms mediating muscarinic enhancement of GABAergic synaptic transmission in the spinal cord.

Authors:  H-M Zhang; S-R Chen; Y-Q Cai; T E Richardson; L C Driver; G Lopez-Berestein; H-L Pan
Journal:  Neuroscience       Date:  2008-12-07       Impact factor: 3.590

8.  Effects of cholinesterase inhibition in supraspinal and spinal neural pathways on the micturition reflex in rats.

Authors:  Hitoshi Masuda; Michel B Chancellor; Kazunori Kihara; Yasuyuki Sakai; Fumitaka Koga; Hiroshi Azuma; William C de Groat; Naoki Yoshimura
Journal:  BJU Int       Date:  2009-03-30       Impact factor: 5.588

9.  Additive interaction of intrathecal ginsenosides and neostigmine in the rat formalin test.

Authors:  Cheon-Hee Park; Park-Ne Kim; Seong-Heon Lee; Myung Ha Yoon
Journal:  Korean J Anesthesiol       Date:  2013-02-15

10.  Investigation of the presence and antinociceptive function of muscarinic acetylcholine receptors in the African naked mole-rat (Heterocephalus glaber).

Authors:  Kristine B Jørgensen; Karen Krogh-Jensen; Darryl S Pickering; Titus I Kanui; Klas S P Abelson
Journal:  J Comp Physiol A Neuroethol Sens Neural Behav Physiol       Date:  2015-10-31       Impact factor: 1.836
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