Literature DB >> 3840090

Organ selectivity of hexahydrosiladifenidol in blocking pre- and postjunctional muscarinic receptors studied in guinea-pig ileum and rat heart.

H Fuder, H Kilbinger, H Müller.   

Abstract

Pre- and postjunctional pA2 values of the muscarinic antagonist hexahydrosiladifenidol were determined with guinea-pig ileum and rat heart. Hexahydrosiladifenidol did not discriminate between pre- and postjunctional receptors within the same organ but was more potent on the ileum (20-80 times) than on the heart. It is concluded that pre- and postjunctional muscarinic receptors in the heart may differ from those in the ileum.

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Year:  1985        PMID： 3840090     DOI： 10.1016/0014-2999(85)90352-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  18 in total

1.  Pharmacokinetic properties of the antimuscarinic drug [3H]-hexahydro-sila-difenidol in the rat.

Authors:  N M Rettenmayr; J F Rodrigues de Miranda; N V Rijntjes; F G Russel; C A van Ginneken; C Strohmann; R Tacke; G Lambrecht; E Mutschler
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-08       Impact factor: 3.000

2.  Muscarine receptor types mediating autoinhibition of acetylcholine release and sphincter contraction in the guinea-pig iris.

Authors:  I T Bognar; M T Wesner; H Fuder
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990 Jan-Feb       Impact factor: 3.000

3.  Different muscarinic receptors mediate autoinhibition of acetylcholine release and vagally-induced vasoconstriction in the rat isolated perfused heart.

Authors:  I T Bognar; B Beinhauer; P Kann; H Fuder
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-04       Impact factor: 3.000

4.  Muscarinic cholinoceptors in the human heart: demonstration, subclassification, and distribution.

Authors:  N M Deighton; S Motomura; D Borquez; H R Zerkowski; N Doetsch; O E Brodde
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990 Jan-Feb       Impact factor: 3.000

5.  Differential effects of pertussis toxin and lithium on muscarinic responses in the atria and ileum: evidence for receptor heterogeneity.

Authors:  R M Eglen; M M Huff; W W Montgomery; R L Whiting
Journal:  Br J Pharmacol       Date:  1987-05       Impact factor: 8.739

6.  Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter.

Authors:  M Hernández; U Símonsen; D Prieto; L Rivera; P García; E Ordaz; A García-Sacristán
Journal:  Br J Pharmacol       Date:  1993-12       Impact factor: 8.739

7.  Glycopyrronium bromide blocks differentially responses mediated by muscarinic receptor subtypes.

Authors:  H Fuder; M Meincke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-06       Impact factor: 3.000

8.  The relative potencies of cholinomimetics and muscarinic antagonists on the rat iris in vivo: effects of pH on potency of pirenzepine and telenzepine.

Authors:  J J Hagan; B van der Heijden; C L Broekkamp
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-11       Impact factor: 3.000

9.  Characterization of prejunctional muscarinic autoreceptors in the guinea-pig trachea.

Authors:  H Kilbinger; R Schneider; H Siefken; D Wolf; G D'Agostino
Journal:  Br J Pharmacol       Date:  1991-07       Impact factor: 8.739

10.  AF-DX 116 differentiates between prejunctional muscarine receptors located on noradrenergic and cholinergic nerves.

Authors:  F Dammann; H Fuder; A Giachetti; E Giraldo; H Kilbinger; R Micheletti
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-03       Impact factor: 3.000
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