Literature DB >> 3840029

The effects of sucralfate upon phenytoin absorption in man.

H L Smart, K W Somerville, J Williams, A Richens, M J Langman.   

Abstract

The possible influence of sucralfate on phenytoin absorption was investigated in a double-blind, placebo controlled study. Concomitant administration of 1 g sucralfate reduced the absorption of 300 mg phenytoin capsules by 20% as measured by the area under the curve from 0-48 h. This could be of significance in epileptic patients stabilised on phenytoin in whom sucralfate is used in ulcer treatment.

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Year:  1985        PMID： 3840029      PMCID： PMC1400695          DOI： 10.1111/j.1365-2125.1985.tb05067.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  3 in total

1.  Sucralfate and warfarin.

Authors:  D Mungall; R L Talbert; C Phillips; D Jaffe; T M Ludden
Journal:  Ann Intern Med       Date:  1983-04       Impact factor: 25.391

2.  A double-blind placebo controlled study to examine effects of sucralfate on paracetamol absorption.

Authors:  F Kamali; J R Fry; H L Smart; G D Bell
Journal:  Br J Clin Pharmacol       Date:  1985-01       Impact factor: 4.335

3.  Cimetidine-sucralfate drug interaction.

Authors:  W A Ritschel; P S Banerjee; H P Koch; M Czeijka
Journal:  Methods Find Exp Clin Pharmacol       Date:  1984-05
  3 in total
  7 in total

Review 1.  Pharmacokinetic drug interactions with phenytoin (Part II).

Authors:  R L Nation; A M Evans; R W Milne
Journal:  Clin Pharmacokinet       Date:  1990-02       Impact factor: 6.447

Review 2.  Drug interactions that matter. A critical reappraisal.

Authors:  G T McInnes; M J Brodie
Journal:  Drugs       Date:  1988-07       Impact factor: 9.546

Review 3.  Clinical Drug-Drug Pharmacokinetic Interaction Potential of Sucralfate with Other Drugs: Review and Perspectives.

Authors:  Suresh P Sulochana; Muzeeb Syed; Devaraj V Chandrasekar; Ramesh Mullangi; Nuggehally R Srinivas
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2016-10       Impact factor: 2.441

4.  Oral phenytoin pharmacokinetics during omeprazole therapy.

Authors:  P J Prichard; R P Walt; G K Kitchingman; K W Somerville; M J Langman; J Williams; A Richens
Journal:  Br J Clin Pharmacol       Date:  1987-10       Impact factor: 4.335

5.  In vivo interaction of ketoconazole and sucralfate in healthy volunteers.

Authors:  P L Carver; R R Berardi; M J Knapp; J M Rider; C A Kauffman; S F Bradley; M Atassi
Journal:  Antimicrob Agents Chemother       Date:  1994-02       Impact factor: 5.191

Review 6.  Antiepileptic drugs. A review of clinically significant drug interactions.

Authors:  P N Patsalos; J S Duncan
Journal:  Drug Saf       Date:  1993-09       Impact factor: 5.606

Review 7.  Science review: The use of proton pump inhibitors for gastric acid suppression in critical illness.

Authors:  Stephen Brett
Journal:  Crit Care       Date:  2004-10-08       Impact factor: 9.097
  7 in total

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