| Literature DB >> 3839531 |
A Martin, P L Wu, Z Liron, S Cohen.
Abstract
In nonpolar solvents a solute may self-associate through polar interactions, exposing its nonpolar surface to a solvent with a low solubility parameter, delta 1. In polar solvents a solute is solvated, presumably, by the polar groups of the solvent. This "chameleonic" effect results in different solubility parameters for a solute, depending on the polarity of the solvent. This report presents data for solute solubility parameters in solvents of variable polarity and gives suggestions for dealing with the chameleonic effect associated with solute-solvent interaction.Mesh:
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Year: 1985 PMID: 3839531 DOI: 10.1002/jps.2600740611
Source DB: PubMed Journal: J Pharm Sci ISSN: 0022-3549 Impact factor: 3.534