Literature DB >> 3839453

Specific regulation of vasoactive intestinal polypeptide biosynthesis by phorbol ester in bovine chromaffin cells.

R M Pruss, J R Moskal, L E Eiden, M C Beinfeld.   

Abstract

Two neuropeptides, enkephalin and vasoactive intestinal polypeptide (VIP), are simultaneously increased in cultures of bovine chromaffin cells after diverse treatments including elevation of cAMP, application of nicotine, or chronic depolarization. We now show that phorbol esters can specifically elevate VIP in cultured chromaffin cells without changing the amount of enkephalin. Peptide histidine isoleucine, a VIP-related peptide, is also expressed concomitantly with VIP after treatment with phorbol ester. Immunocytochemical examination of drug-treated cells defines a subpopulation of chromaffin cells which are responsive to phorbol ester stimulation. The unique ability of phorbol esters to selectively regulate VIP expression indicates the presence of independent mechanisms for controlling the expression of individual neuropeptides in chromaffin cells.

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Year:  1985        PMID： 3839453     DOI： 10.1210/endo-117-3-1020

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  11 in total

1.  Agonist-dependent patterns of cytosolic Ca2+ changes in single bovine adrenal chromaffin cells: relationship to catecholamine release.

Authors:  K A Stauderman; M M Murawsky; R M Pruss
Journal:  Cell Regul       Date:  1990-08

2.  Histamine-induced increases in cyclic AMP levels in bovine adrenal medullary cells.

Authors:  P D Marley; K A Thomson; K Jachno; M J Johnston
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739

Review 3.  Regulation of the biosynthesis of large dense-core vesicles in chromaffin cells and neurons.

Authors:  H Winkler; R Fischer-Colbrie
Journal:  Cell Mol Neurobiol       Date:  1998-04       Impact factor: 5.046

Review 4.  Regulation of VIP gene expression in general. Human lung cancer cells in particular.

Authors:  A Davidson; T W Moody; I Gozes
Journal:  J Mol Neurosci       Date:  1996       Impact factor: 3.444

Review 5.  Vasoactive intestinal peptide.

Authors:  S I Said
Journal:  J Endocrinol Invest       Date:  1986-04       Impact factor: 4.256

6.  Histamine-induced Ca2+ entry precedes Ca2+ mobilization in bovine adrenal chromaffin cells.

Authors:  T R Cheek; M M Murawsky; K A Stauderman
Journal:  Biochem J       Date:  1994-12-01       Impact factor: 3.857

7.  Coincident elevation of cAMP and calcium influx by PACAP-27 synergistically regulates vasoactive intestinal polypeptide gene transcription through a novel PKA-independent signaling pathway.

Authors:  Carol Hamelink; Hyeon-Woo Lee; Yun Chen; Maurizio Grimaldi; Lee E Eiden
Journal:  J Neurosci       Date:  2002-07-01       Impact factor: 6.167

8.  The role of caffeine-sensitive Ca2+ stores in agonist- and inositol 1,4,5-trisphosphate-induced Ca2+ release from bovine adrenal chromaffin cells.

Authors:  K A Stauderman; R A McKinney; M M Murawsky
Journal:  Biochem J       Date:  1991-09-15       Impact factor: 3.857

Review 9.  VIP: molecular biology and neurobiological function.

Authors:  I Gozes; D E Brenneman
Journal:  Mol Neurobiol       Date:  1989       Impact factor: 5.590

10.  Estrogen regulation of vasoactive intestinal peptide mRNA in rat hypothalamus.

Authors:  I Gozes; H Werner; M Fawzi; A Abdelatty; Y Shani; M Fridkin; Y Koch
Journal:  J Mol Neurosci       Date:  1989       Impact factor: 3.444
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