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Literature DB >> 3839224

Dihydromonacolin L and monacolin X, new metabolites which inhibit cholesterol biosynthesis.

A Endo, K Hasumi, T Nakamura, M Kunishima, M Masuda.

Abstract

Dihydromonacolin L and monacolin X those are structurally related to monacolin K, a potent inhibitor of cholesterol biosynthesis, were isolated from cultures of a mutant of Monascus ruber. The structures of these two metabolites were determined by a combination of physical techniques. Data for dihydromonacolin L and monacolin X as inhibitors of hydroxymethylglutaryl-CoA reductase and sterol biosynthesis in vitro are also given.

Entities: Chemical Species

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Year: 1985 PMID： 3839224 DOI： 10.7164/antibiotics.38.321

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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3. FT-ICR-MS characterization of intermediates in the biosynthesis of the α-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF.

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Dihydromonacolin L and monacolin X, new metabolites which inhibit cholesterol biosynthesis.

1. Nature-inspired total synthesis of (-)-fusarisetin A.

2. Time response of cholesterol synthesis inhibition by compactin-related compounds. In vitro quantitation of the "escape phenomenon".

3. FT-ICR-MS characterization of intermediates in the biosynthesis of the α-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF.

4. Acyltransferase mediated polyketide release from a fungal megasynthase.

5. Comparison of the effect of six compactin-related compounds on cholesterol synthesis in five human cell types.

Review 6. Chemistry, biochemistry, and pharmacology of HMG-CoA reductase inhibitors.

7. Effect of rice--glycerol complex medium on the production of Lovastatin by Monascus ruber.

8. Microbial production and biomedical applications of lovastatin.

9. Isolation, Identification, and Characterization of an Unknown Impurity in Lovastatin EP.

10. Perspectives on Functional Red Mold Rice: Functional Ingredients, Production, and Application.