Literature DB >> 3838994

Stimulation of phospholipase A2 activity by oxygen-derived free radicals in isolated brain capillaries.

A M Au, P H Chan, R A Fishman.   

Abstract

An exogenous free radical generating system added to isolated brain capillaries induces degradation of phospholipids. This inductive effect reflects increased phospholipase activities as measured by fatty acid composition of various phospholipid fractions. The correlation of phospholipid degradation with stimulation of phospholipases was further investigated by using cationic amphiphilic agents, which are known to be phospholipase A2 inhibitors. The breakdown of phospholipids was inhibited by the pretreatment of isolated capillaries with these drugs.

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Year:  1985        PMID： 3838994     DOI： 10.1002/jcb.240270413

Source DB:  PubMed          Journal:  J Cell Biochem        ISSN： 0730-2312            Impact factor:   4.429


  13 in total

Review 1.  Mechanisms of neuronal cell death in Wernicke's encephalopathy.

Authors:  A S Hazell; K G Todd; R F Butterworth
Journal:  Metab Brain Dis       Date:  1998-06       Impact factor: 3.584

Review 2.  Active oxygen in neuromuscular disorders.

Authors:  A Davison; G Tibbits; Z G Shi; J Moon
Journal:  Mol Cell Biochem       Date:  1988-12       Impact factor: 3.396

3.  No evidence for lysophospholipid formation during peroxidation of phospholipids by NADPH-cytochrome P-450 reductase and iron ions.

Authors:  J Kostrucha; H Kappus
Journal:  Arch Toxicol       Date:  1987       Impact factor: 5.153

4.  Thiobarbituric acid-reactive material content and enzymatic protection against peroxidative damage during the course of cryogenic rabbit brain edema.

Authors:  N Avéret; M Coussemacq; F Cohadon
Journal:  Neurochem Res       Date:  1990-08       Impact factor: 3.996

5.  Hydrogen peroxide-induced alterations in prostaglandin secretion in the rat colon in vitro.

Authors:  S N Murthy; C G Cooney; H R Clearfield
Journal:  Inflammation       Date:  1990-12       Impact factor: 4.092

6.  Incorporation of marine lipids into mitochondrial membranes increases susceptibility to damage by calcium and reactive oxygen species: evidence for enhanced activation of phospholipase A2 in mitochondria enriched with n-3 fatty acids.

Authors:  C D Malis; P C Weber; A Leaf; J V Bonventre
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

7.  Oxygen metabolites stimulate release of high-molecular-weight glycoconjugates by cell and organ cultures of rodent respiratory epithelium via an arachidonic acid-dependent mechanism.

Authors:  K B Adler; W J Holden-Stauffer; J E Repine
Journal:  J Clin Invest       Date:  1990-01       Impact factor: 14.808

8.  Membrane-derived second messenger regulates x-ray-mediated tumor necrosis factor alpha gene induction.

Authors:  D E Hallahan; S Virudachalam; J Kuchibhotla; D W Kufe; R R Weichselbaum
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205

9.  Role of lipid structure in the activation of phospholipase A2 by peroxidized phospholipids.

Authors:  L R McLean; K A Hagaman; W S Davidson
Journal:  Lipids       Date:  1993-06       Impact factor: 1.880

10.  Pharmacological studies on dithranol-induced irritative dermatitis in mice.

Authors:  L Kemény; M Csató; A Dobozy
Journal:  Arch Dermatol Res       Date:  1989       Impact factor: 3.017
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