Literature DB >> 3838385

Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence.

A K Jaiswal, F J Gonzalez, D W Nebert.   

Abstract

Induction of cytochrome P1-450 has been linked to susceptibility to certain chemically induced cancers in mouse and man. Treatment of the human cell line MCF-7 with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) results in high levels of aryl hydrocarbon (benzo[a]pyrene) hydroxylase (P1-450) activity. This cell line was used to isolate a human P1-450 full-length complementary DNA (cDNA) clone. The cDNA is 2566 nucleotides in length, encodes a polyadenylated messenger RNA (2.8 kilobases in length), and has a continuous reading frame producing a protein with 512 residues (molecular weight, 58,151). The human P1-450 cDNA and protein are 63 percent and 80 percent similar to mouse P1-450 cDNA and protein, respectively. Whereas the mouse TCDD-inducible P-450 gene subfamily has two members (P1-450 and P3-450), the human TCDD-inducible gene subfamily appears to have only one gene (P1-450).

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Year:  1985        PMID： 3838385     DOI： 10.1126/science.3838385

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  37 in total

Review 1.  Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility.

Authors:  M M de Jong; I M Nolte; G J te Meerman; W T A van der Graaf; J C Oosterwijk; J H Kleibeuker; M Schaapveld; E G E de Vries
Journal:  J Med Genet       Date:  2002-04       Impact factor: 6.318

2.  Identification of a functionally conserved surface region of rat cytochromes P450IA.

Authors:  R J Edwards; A M Singleton; B P Murray; S Murray; A R Boobis; D S Davies
Journal:  Biochem J       Date:  1991-09-15       Impact factor: 3.857

Review 3.  The use of reverse transcriptase-polymerase chain reaction (RT-PCR) to investigate specific gene expression in multidrug-resistant cells.

Authors:  L O'Driscoll; C Daly; M Saleh; M Clynes
Journal:  Cytotechnology       Date:  1993       Impact factor: 2.058

4.  Induction of cytochrome P450 1A by cow milk-based formula: a comparative study between human milk and formula.

Authors:  Haibo Xu; Ratheishan Rajesan; Patricia Harper; Richard B Kim; Bo Lonnerdal; Mingdong Yang; Satoko Uematsu; Janine Hutson; Jo Watson-MacDonell; Shinya Ito
Journal:  Br J Pharmacol       Date:  2005-09       Impact factor: 8.739

5.  Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.

Authors:  P H Beaune; D R Umbenhauer; R W Bork; R S Lloyd; F P Guengerich
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

6.  TCDD, dietary iron and hepatic iron distribution in female rats.

Authors:  Z A Al-Bayati; S J Stohs; W A Al-Turk
Journal:  Bull Environ Contam Toxicol       Date:  1987-02       Impact factor: 2.151

7.  Two RFLPs associated with the human P1450 gene linked to the MPI locus on chromosome 15 [HGM8 D15S8].

Authors:  A K Jaiswal; D W Nebert
Journal:  Nucleic Acids Res       Date:  1986-05-27       Impact factor: 16.971

8.  2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced lipid peroxidation in hepatic and extrahepatic tissues of male and female rats.

Authors:  Z A Al-Bayati; W J Murray; S J Stohs
Journal:  Arch Environ Contam Toxicol       Date:  1987-03       Impact factor: 2.804

9.  Identification of cytochrome P-450 1A (CYP1A) genes from two teleost fish, toadfish (Opsanus tau) and scup (Stenotomus chrysops), and phylogenetic analysis of CYP1A genes.

Authors:  H G Morrison; M F Oleksiak; N W Cornell; M L Sogin; J J Stegeman
Journal:  Biochem J       Date:  1995-05-15       Impact factor: 3.857

10.  Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation.

Authors:  F J Gonzalez; B J Song; J P Hardwick
Journal:  Mol Cell Biol       Date:  1986-08       Impact factor: 4.272
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