Literature DB >> 3838201

Location of functional regions of acetylcholine receptor alpha-subunit by site-directed mutagenesis.

M Mishina, T Tobimatsu, K Imoto, K Tanaka, Y Fujita, K Fukuda, M Kurasaki, H Takahashi, Y Morimoto, T Hirose.   

Abstract

The availability of cloned cDNAs encoding the four subunits of the Torpedo acetylcholine receptor, which can be expressed to make functional receptors in Xenopus oocytes, has made possible a detailed investigation of the functions of the different structural components of the receptor. The functional analysis of receptors with alpha-subunits altered at specific sites by site-directed mutagenesis of the cDNA has allowed the location of specific regions of the alpha-subunit molecule involved in acetylcholine binding and forming a transmembrane ionic channel.

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Year:  1985        PMID： 3838201     DOI： 10.1038/313364a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  74 in total

1.  Rearrangement of nicotinic receptor alpha subunits during formation of the ligand binding sites.

Authors:  M Mitra; C P Wanamaker; W N Green
Journal:  J Neurosci       Date:  2001-05-01       Impact factor: 6.167

2.  Regulation of nicotinic acetylcholine receptor function by adenine nucleotides.

Authors:  V A Eterović; L Li; A Palma; M G McNamee
Journal:  Cell Mol Neurobiol       Date:  1990-09       Impact factor: 5.046

Review 3.  Use of Xenopus oocytes for the functional expression of plasma membrane proteins.

Authors:  E Sigel
Journal:  J Membr Biol       Date:  1990-09       Impact factor: 1.843

4.  Creating an α7 nicotinic acetylcholine recognition domain from the acetylcholine-binding protein: crystallographic and ligand selectivity analyses.

Authors:  Akos Nemecz; Palmer Taylor
Journal:  J Biol Chem       Date:  2011-10-18       Impact factor: 5.157

5.  Primary structure of an agonist binding subunit of the nicotinic acetylcholine receptor from bovine adrenal chromaffin cells.

Authors:  M Criado; L Alamo; A Navarro
Journal:  Neurochem Res       Date:  1992-03       Impact factor: 3.996

Review 6.  Activation of skeletal muscle nicotinic acetylcholine receptors.

Authors:  C J Lingle; D Maconochie; J H Steinbach
Journal:  J Membr Biol       Date:  1992-03       Impact factor: 1.843

7.  Expression of functional pituitary somatostatin receptors in Xenopus oocytes.

Authors:  M M White; T Reisine
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

8.  Two subsites in the binding domain of the acetylcholine receptor: an aromatic subsite and a proline subsite.

Authors:  S G Kachalsky; B S Jensen; D Barchan; S Fuchs
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-07       Impact factor: 11.205

9.  Effect of chemical modification of extracellular histidyl residues on the channel properties of the nicotinic acetylcholine receptor.

Authors:  C B Bouzat; H D Lacorazza; M Biscoglio de Jiménez Bonino; F J Barrantes
Journal:  Pflugers Arch       Date:  1993-06       Impact factor: 3.657

10.  Altered patterns of N-linked glycosylation of the Torpedo acetylcholine receptor expressed in Xenopus oocytes.

Authors:  A L Buller; M M White
Journal:  J Membr Biol       Date:  1990-05       Impact factor: 1.843
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