Literature DB >> 3837966

A rational scientific basis for subclassification of antiarrhythmic drugs.

D C Harrison.   

Abstract

The subclassification of Vaughan Williams Class I agents into IA, IB, and IC groups on empiric and clinical grounds has recently been given a cellular electrophysiologic scientific basis. Based on the kinetics of association and dissociation of the drugs with sodium channels, 3 distinct subgroups can be defined. These observations help to explain the clinical utility of the algorithms to use the agents in patients and provide a reference for discussing the new drugs with antiarrhythmic properties being discovered.

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Year:  1986        PMID： 3837966      PMCID： PMC2279697     

Source DB:  PubMed          Journal:  Trans Am Clin Climatol Assoc        ISSN： 0065-7778


  9 in total

1.  Antiarrhythmic drug classification: new science and practical applications.

Authors:  D C Harrison
Journal:  Am J Cardiol       Date:  1985-07-01       Impact factor: 2.778

Review 2.  New antiarrhythmic drugs: their place in therapy.

Authors:  D L Keefe; R E Kates; D C Harrison
Journal:  Drugs       Date:  1981-11       Impact factor: 9.546

3.  Voltage- and time-dependent depression of maximum rate of depolarisation of guinea-pig ventricular action potentials by two new antiarrhythmic drugs, flecainide and lorcainide.

Authors:  T J Campbell; E M Vaughan Williams
Journal:  Cardiovasc Res       Date:  1983-05       Impact factor: 10.787

4.  Kinetics of onset of rate-dependent effects of Class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification.

Authors:  T J Campbell
Journal:  Cardiovasc Res       Date:  1983-06       Impact factor: 10.787

Review 5.  Disopyramide.

Authors:  E M Vaughan Williams
Journal:  Ann N Y Acad Sci       Date:  1984       Impact factor: 5.691

6.  Test of a model of antiarrhythmic drug action. Effects of quinidine and lidocaine on myocardial conduction.

Authors:  L Hondeghem; B G Katzung
Journal:  Circulation       Date:  1980-06       Impact factor: 29.690

7.  Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA.

Authors:  K R Courtney
Journal:  J Pharmacol Exp Ther       Date:  1975-11       Impact factor: 4.030

8.  Encainide and its metabolites. Comparative effects in man on ventricular arrhythmia and electrocardiographic intervals.

Authors:  E L Carey; H J Duff; D M Roden; R K Primm; G R Wilkinson; T Wang; J A Oates; R L Woosley
Journal:  J Clin Invest       Date:  1984-02       Impact factor: 14.808

9.  Intracoronary thrombus in nontransmural myocardial infarction and in unstable angina pectoris.

Authors:  J B Mandelkorn; N M Wolf; S Singh; J A Shechter; R I Kersh; D M Rodgers; M B Workman; L G Bentivoglio; S M LaPorte; S G Meister
Journal:  Am J Cardiol       Date:  1983-07       Impact factor: 2.778
  9 in total
  2 in total

Review 1.  [Class I antiarrhythmic drugs: mechanisms, contraindications, and current indications].

Authors:  C Pott; D G Dechering; A Muszynski; S Zellerhoff; A Bittner; K Wasmer; G Mönnig; L Eckardt
Journal:  Herzschrittmacherther Elektrophysiol       Date:  2010-12

2.  Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+β1 Model.

Authors:  Dieter V Van de Sande; Ivan Kopljar; Ard Teisman; David J Gallacher; Dirk J Snyders; Hua Rong Lu; Alain J Labro
Journal:  Front Pharmacol       Date:  2019-12-11       Impact factor: 5.810
  2 in total

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