| Literature DB >> 3836123 |
N K Borowy, H Hirumi, H K Waithaka, G Mkoji.
Abstract
A rapid and simple assay for in vitro drug screening has been established using the mammalian feeder layer cell system for continuous cultivation of infective bloodstream forms of Trypanosoma brucei brucei. A total of 21 trypanocides have been tested. Differences in sensitivity to standard trypanocides were detected among drug-susceptible isolates and strains of T. b. brucei. This assay may thus be of potential use for rapid detection of new drug-resistant isolates of T. b. brucei.Entities:
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Year: 1985 PMID： 3836123
Source DB: PubMed Journal: Drugs Exp Clin Res ISSN： 0378-6501