Literature DB >> 3834070

Effect of protein binding on steady-state equations.

J G Wagner.   

Abstract

Previously published steady-state equations assumed elimination of total drug. The equations have been derived to cover the case where only free (unbound) drug is eliminated. The equation for oral administration is the same in both cases. The equation for intravenous administration has the same form, but the interpretation of Km is different.

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Year:  1985        PMID： 3834070     DOI： 10.1007/bf01059338

Source DB:  PubMed          Journal:  J Pharmacokinet Biopharm        ISSN： 0090-466X


  3 in total

1.  Letter: Effect of plasma protein binding on elimination of warfarin.

Authors:  G Levy; A Yacobi
Journal:  J Pharm Sci       Date:  1974-05       Impact factor: 3.534

2.  A nonlinear physiologic pharmacokinetic model: I. Steady-state.

Authors:  J G Wagner; G J Szpunar; J J Ferry
Journal:  J Pharmacokinet Biopharm       Date:  1985-02

3.  Pharmacokinetic concepts - drug binding, apparent volume of distribution and clearance.

Authors:  M Gibaldi; J R Koup
Journal:  Eur J Clin Pharmacol       Date:  1981       Impact factor: 2.953
  3 in total

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