Literature DB >> 3831387

Type-A retrovirus particles in heterohybridomas: precaution for human monoclonal antibody purification.

J C Herr, D R Spell.   

Abstract

Fine structural features of the murine myeloma MHFP-1 and two heterohybridomas secreting human IgM monoclonal antibody were examined. Intracisternal type-A retrovirus particles were found in both MHFP-1 and the heterohydribomas constructed by fusing MHFP-1 and human peripheral blood lymphocytes. The implications of this finding for the purification of human monoclonal antibody for therapeutic applications is discussed.

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Year:  1985        PMID: 3831387     DOI: 10.1016/0889-1605(85)90130-2

Source DB:  PubMed          Journal:  J Ultrastruct Res        ISSN: 0022-5320


  1 in total

1.  Cytoplasmic inclusions within developing mouse retinal photoreceptor cells maintained in culture: possible type A retrovirus particles?

Authors:  M M Bird
Journal:  J Anat       Date:  1988-02       Impact factor: 2.610

  1 in total

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