Literature DB >> 3830884

There is no such thing as ageing, and cancer is not related to it.

R Peto, S E Parish, R G Gray.   

Abstract

Several separate cellular processes have to accumulate in a normal cell to alter it into the seed of a growing carcinoma. Even though cancer is much commoner in the old than in the young, there is no good evidence whatever that these separate processes have any systematic tendency to take place more readily among old than among young adults. (Indeed, there are some instances in which carcinogenic treatments actually elicit cancer less rapidly among the old!) There are obvious evolutionary reasons why substantial cancer risks should be delayed until the end of the usual lifespan, and it appears that this is achieved chiefly not by having the component processes of neoplastic transformation themselves particularly dependent on age, but simply by requiring not one, but several, of them en route from full normality to full malignancy, and by giving at least some of them an extraordinarily low daily probability. The daily probabilities of these separate events are, of course, under evolutionary influence, and some of them appear to have changed by orders of magnitude over the tens of millions of years of evolution that separate humanity from various short-lived animals.

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Year:  1985        PMID: 3830884

Source DB:  PubMed          Journal:  IARC Sci Publ        ISSN: 0300-5038


  9 in total

1.  Trends in cigarette consumption cannot fully explain trends in British lung cancer rates.

Authors:  P N Lee; B A Forey
Journal:  J Epidemiol Community Health       Date:  1998-02       Impact factor: 3.710

2.  Quantitative implications of the approximate irrelevance of mammalian body size and lifespan to lifelong cancer risk.

Authors:  Richard Peto
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2015-07-19       Impact factor: 6.237

Review 3.  Aging, nutrient signaling, hematopoietic senescence, and cancer.

Authors:  Priya Balasubramanian; Valter D Longo
Journal:  Crit Rev Oncog       Date:  2013

4.  Age and dose-dependent carcinogenic effects of N-nitrosomethylurea administered intraperitoneally in a single dose to young and adult female mice.

Authors:  V N Anisimov
Journal:  J Cancer Res Clin Oncol       Date:  1993       Impact factor: 4.553

5.  Effect of age on dose-response relationship in carcinogenesis induced by single administration of N-nitrosomethylurea in female rats.

Authors:  V N Anisimov
Journal:  J Cancer Res Clin Oncol       Date:  1988       Impact factor: 4.553

6.  Time Trends And Age-Period-Cohort Effects On The Incidence Of Gastric Cancer In Changle From 2003 To 2012.

Authors:  Yongtian Lin; Shaowei Lin; Jianshun Chen; Lici Chen; Tao Tao; Siying Wu
Journal:  Cancer Manag Res       Date:  2019-10-10       Impact factor: 3.989

7.  An essay on the nominal vs. real definitions of aging.

Authors:  Aleksei G Golubev
Journal:  Biogerontology       Date:  2021-06-06       Impact factor: 4.277

8.  Trends and Age-Period-Cohort Effects on the Prevalence, Incidence and Mortality of Hepatocellular Carcinoma from 2008 to 2017 in Tianjin, China.

Authors:  Chengyu Liu; Jing Wu; Zheng Chang
Journal:  Int J Environ Res Public Health       Date:  2021-06-04       Impact factor: 3.390

9.  Absence of cytoglobin promotes multiple organ abnormalities in aged mice.

Authors:  Le Thi Thanh Thuy; Tuong Thi Van Thuy; Yoshinari Matsumoto; Hoang Hai; Yoshihiro Ikura; Katsutoshi Yoshizato; Norifumi Kawada
Journal:  Sci Rep       Date:  2016-05-05       Impact factor: 4.379

  9 in total

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