Literature DB >> 3828978

Short-term quantitative in vitro cytotoxicity assay involving an S-9 activating system.

E Borenfreund, J A Puerner.   

Abstract

Mouse 3T3 fibroblasts grown in 96-well microtiter plates are used for a test which incorporates an S-9 mixed function oxidase system into a neutral red viability assay for the assessment of the acute cytotoxicity of xenobiotics in vitro. This sensitive, quantitative, semi-automated assay was suitable for the rapid screening of a broad spectrum of substances, including pharmaceuticals, carcinogens, and anti-neoplastic agents. The test was applicable to the analysis of toxic ranges, for the detection of biotransformability of parent compounds and for the evaluation of the cytotoxic effects of chemotherapeutic agents.

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Year:  1987        PMID： 3828978     DOI： 10.1016/0304-3835(87)90173-x

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  10 in total

1.  Cell culture systems and in vitro toxicity testing. Technical report no. 4 of the Johns Hopkins Center for Alternatives to Animal Testing (CAAT): technical workshop of June 13-15, 1990.

Authors: 
Journal:  Cytotechnology       Date:  1992       Impact factor: 2.058

2.  Rapid chemosensitivity assay with human normal and tumor cells in vitro.

Authors:  E Borenfreund; H Babich; N Martin-Alguacil
Journal:  In Vitro Cell Dev Biol       Date:  1990-11

3.  In vitro cytotoxicity of heavy metals, acrylamide, and organotin salts to neural cells and fibroblasts.

Authors:  E Borenfreund; H Babich
Journal:  Cell Biol Toxicol       Date:  1987-03       Impact factor: 6.691

4.  Acute cytotoxicities of polynuclear aromatic hydrocarbons determined in vitro with the human liver tumor cell line, HepG2.

Authors:  H Babich; M K Sardana; E Borenfreund
Journal:  Cell Biol Toxicol       Date:  1988-09       Impact factor: 6.691

5.  Toxic evaluation of organic extracts from airborne particulate matter in Puerto Rico.

Authors:  D R Reyes; O Rosario; J F Rodriguez; B D Jimenez
Journal:  Environ Health Perspect       Date:  2000-07       Impact factor: 9.031

6.  Verbesina encelioides: cytotoxicity, cell cycle arrest, and oxidative DNA damage in human liver cancer (HepG2) cell line.

Authors:  Mai M Al-Oqail; Maqsood A Siddiqui; Ebtesam S Al-Sheddi; Quaiser Saquib; Javed Musarrat; Abdulaziz A Al-Khedhairy; Nida N Farshori
Journal:  BMC Complement Altern Med       Date:  2016-05-10       Impact factor: 3.659

7.  Anticancer Potential of Green Synthesized Silver Nanoparticles Using Extract of Nepeta deflersiana against Human Cervical Cancer Cells (HeLA).

Authors:  Ebtesam S Al-Sheddi; Nida N Farshori; Mai M Al-Oqail; Shaza M Al-Massarani; Quaiser Saquib; Rizwan Wahab; Javed Musarrat; Abdulaziz A Al-Khedhairy; Maqsood A Siddiqui
Journal:  Bioinorg Chem Appl       Date:  2018-11-01       Impact factor: 7.778

8.  Transient overexpression of adh8a increases allyl alcohol toxicity in zebrafish embryos.

Authors:  Nils Klüver; Julia Ortmann; Heidrun Paschke; Patrick Renner; Axel P Ritter; Stefan Scholz
Journal:  PLoS One       Date:  2014-03-03       Impact factor: 3.240

9.  Corn Silk (Zea mays L.) Induced Apoptosis in Human Breast Cancer (MCF-7) Cells via the ROS-Mediated Mitochondrial Pathway.

Authors:  Mai M Al-Oqail; Ebtesam S Al-Sheddi; Nida N Farshori; Shaza M Al-Massarani; Eman A Al-Turki; Javed Ahmad; Abdulaziz A Al-Khedhairy; Maqsood A Siddiqui
Journal:  Oxid Med Cell Longev       Date:  2019-10-20       Impact factor: 6.543

10.  Curcumin-Galactomannoside Complex inhibits the Proliferation of Human Cervical Cancer Cells: Possible Role in Cell Cycle Arrest and Apoptosis.

Authors:  Ratheesh M; Svenia P Jose; Krishnakumar Im; Sandya S; Sangeeth Saji; Sheethal S
Journal:  Asian Pac J Cancer Prev       Date:  2021-06-01
  10 in total

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