Literature DB >> 3828807

Neurotensin self-injection in the ventral tegmental area.

P W Glimcher, A A Giovino, B G Hoebel.   

Abstract

Earlier work with the conditioned place-preference paradigm suggested that neurotensin (NT) acts as a behavioral reinforcer when microinjected into the ventral tegmental area (VTA) of the midbrain. We report here that animals will perform an operant task to obtain microinfusions of NT into the VTA. Rats reliably pressed a lever to obtain NT infusions while neglecting an identical but inactive lever. Substitution of saline for NT initiated response extinction; following the reintroduction of NT, reliable responding resumed. These results extend earlier work suggesting that NT in the VTA can be a positive reinforcer.

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Year:  1987        PMID： 3828807     DOI： 10.1016/0006-8993(87)90134-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  24 in total

Review 1.  The role of neurotensin in central nervous system pathophysiology: what is the evidence?

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2.  Diverse actions of the modulatory peptide neurotensin on central synaptic transmission.

Authors:  Christopher W Tschumi; Michael J Beckstead
Journal:  Eur J Neurosci       Date:  2018-02-28       Impact factor: 3.386

3.  Neurotensin speeds inhibition of dopamine neurons through temporal modulation of GABAA and GABAB receptor-mediated synaptic input.

Authors:  Christopher W Tschumi; Michael J Beckstead
Journal:  Neuropharmacology       Date:  2018-01-05       Impact factor: 5.250

4.  Role of endogenous neurotensin in the behavioral and neuroendocrine effects of cocaine.

Authors:  C Betancur; R Cabrera; E R de Kloet; D Pélaprat; W Rostène
Journal:  Neuropsychopharmacology       Date:  1998-10       Impact factor: 7.853

5.  Effects of neurotensin gene knockout in mice on the behavioral effects of cocaine.

Authors:  F Scott Hall; Marjorie Centeno; Maria T G Perona; Jordan Adair; Paul R Dobner; George R Uhl
Journal:  Psychopharmacology (Berl)       Date:  2011-07-01       Impact factor: 4.530

6.  Bilateral intra-accumbens self-administration of d-amphetamine: antagonism with intra-accumbens SCH-23390 and sulpiride.

Authors:  G D Phillips; T W Robbins; B J Everitt
Journal:  Psychopharmacology (Berl)       Date:  1994-04       Impact factor: 4.530

7.  Loss of neurotensin receptor-1 disrupts the control of the mesolimbic dopamine system by leptin and promotes hedonic feeding and obesity.

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Review 8.  Neural Circuit Motifs in Valence Processing.

Authors:  Kay M Tye
Journal:  Neuron       Date:  2018-10-24       Impact factor: 17.173

9.  Comparison of the locomotor-activating effects of bicuculline infusions into the preoptic area and ventral pallidum.

Authors:  Daniel S Zahm; Zachary M Schwartz; Heather N Lavezzi; Leora Yetnikoff; Kenneth P Parsley
Journal:  Brain Struct Funct       Date:  2013-02-20       Impact factor: 3.270

10.  Unconditional hyperactivity and transient reinforcing effects of NMDA administration into the ventral tegmental area in rats.

Authors:  Satoshi Ikemoto
Journal:  Psychopharmacology (Berl)       Date:  2003-11-21       Impact factor: 4.530
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