Literature DB >> 3827868

The exponential model for a regulatory enzyme. An interpretation of the linear free-energy relationship.

S Ainsworth.   

Abstract

A physical mechanism is suggested to explain the linear free-energy relationship employed in the exponential model for a regulatory enzyme [Ainsworth (1977) J. Theor. Biol. 68, 391-413]. The interpretation depends on the assumption that the structure of the enzyme changes in proportion to its saturation by substrate but at a rate that is low compared with the rates of the association-dissociation reactions of the enzyme-substrate system.

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Year:  1986        PMID： 3827868      PMCID： PMC1147491          DOI： 10.1042/bj2400811

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  31 in total

1.  ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.

Authors:  J MONOD; J WYMAN; J P CHANGEUX
Journal:  J Mol Biol       Date:  1965-05       Impact factor: 5.469

2.  The physical aspects of enzyme functioning.

Authors:  L A Blumenfeld
Journal:  J Theor Biol       Date:  1976-05-21       Impact factor: 2.691

3.  Crystallographic studies of the dynamic properties of lysozyme.

Authors:  P J Artymiuk; C C Blake; D E Grace; S J Oatley; D C Phillips; M J Sternberg
Journal:  Nature       Date:  1979-08-16       Impact factor: 49.962

4.  Macromolecule--small molecule interactions: analytical and graphical reexamination.

Authors:  C J Thompson; I M Klotz
Journal:  Arch Biochem Biophys       Date:  1971-11       Impact factor: 4.013

5.  Stereochemistry of cooperative effects in haemoglobin.

Authors:  M F Perutz
Journal:  Nature       Date:  1970-11-21       Impact factor: 49.962

6.  Location of critical points in the reaction velocity/concentration relationships predicted by the exponential model for a two substrate regulatory enzyme.

Authors:  S Ainsworth; J Kinderlerer
Journal:  Int J Biomed Comput       Date:  1984 Jul-Aug

7.  Exponential model for a two-ligand, regulatory enzyme. Part 3: Performance tests of INDEXP computer programs for determination of model constants from initial velocity data. 2. Experimental data.

Authors:  S Ainsworth; J Kinderlerer; R B Gregory
Journal:  Int J Biomed Comput       Date:  1981-07

8.  The analysis of kinetic data for regulatory enzymes as a function of pH.

Authors:  R B Gregory; S Ainsworth
Journal:  Biochim Biophys Acta       Date:  1981-06-15

9.  The regulatory properties of yeast pyruvate kinase. Effects of NH4+ and K+ concentrations.

Authors:  N Rhodes; C N Morris; S Ainsworth; J Kinderlerer
Journal:  Biochem J       Date:  1986-03-15       Impact factor: 3.857

10.  The regulatory properties of rabbit muscle pyruvate kinase. The influence of substrate concentrations.

Authors:  S Ainsworth; J Kinderlerer; R B Gregory
Journal:  Biochem J       Date:  1983-02-01       Impact factor: 3.857
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