Literature DB >> 3827696

Cholinesterases in cerebrospinal fluid. A longitudinal study in Alzheimer disease.

R Elble, E Giacobini, G F Scarsella.   

Abstract

We measured acetylcholinesterase (AChE) and butyrylcholinesterase activities in the lumbar cerebrospinal fluid (CSF) of 39 patients with dementia of Alzheimer type and 21 age-matched controls. The mean lumbar CSF AChE activity in our patients did not differ significantly from that of controls. The 7S and 11S molecular forms were also unchanged. When CSF was analyzed at six-month intervals, there was no significant decline in AChE activity over a span of 12 months. Our results and those of previous studies demonstrate that CSF AChE is not a useful diagnostic marker of Alzheimer disease.

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Year:  1987        PMID： 3827696     DOI： 10.1001/archneur.1987.00520160041012

Source DB:  PubMed          Journal:  Arch Neurol        ISSN： 0003-9942


  9 in total

1.  Cholinergic deficit in Alzheimer's disease: a study based on CSF and autopsy data.

Authors:  K J Reinikainen; P J Riekkinen; L Paljärvi; H Soininen; E L Helkala; J Jolkkonen; M Laakso
Journal:  Neurochem Res       Date:  1988-02       Impact factor: 3.996

2.  Cholinesterases in the cerebrospinal fluid, plasma, and erythrocytes of patients with Alzheimer's disease.

Authors:  J Sirviö; R Kutvonen; H Soininen; P Hartikainen; P J Riekkinen
Journal:  J Neural Transm       Date:  1989       Impact factor: 3.575

Review 3.  Do cholinesterase inhibitors have disease-modifying effects in Alzheimer's disease?

Authors:  E Giacobini
Journal:  CNS Drugs       Date:  2001       Impact factor: 5.749

4.  Neurotransmitter markers in the cerebrospinal fluid of normal subjects. Effects of aging and other confounding factors.

Authors:  P Hartikainen; H Soininen; K J Reinikainen; J Sirviö; R Soikkeli; P J Riekkinen
Journal:  J Neural Transm Gen Sect       Date:  1991

5.  A long-term follow-up study of cerebrospinal fluid acetylcholinesterase in delirium.

Authors:  H J Koponen; J Sirviö; U Lepola; E Leinonen; P J Riekkinen
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1994       Impact factor: 5.270

6.  Cerebrospinal fluid acetylcholinesterase and choline measurements in Huntington's disease.

Authors:  B V Manyam; E Giacobini; J A Colliver
Journal:  J Neurol       Date:  1990-08       Impact factor: 4.849

7.  Acetylcholine synthesis in human CSF: implications for study of central cholinergic metabolism.

Authors:  S T DeKosky; S W Scheff; C G Hackney
Journal:  Neurochem Res       Date:  1989-02       Impact factor: 3.996

8.  The molecular forms of acetylcholinesterase in cerebrospinal fluid of normal subjects--effect of aging.

Authors:  J Sirviö; Z Rakonczay; P Hartikainen; P Kasa; P J Riekkinen
Journal:  J Neural Transm Gen Sect       Date:  1991

9.  Acetylcholinesterase and butyrylcholinesterase activities in cerebrospinal fluid from different levels of the neuraxis of patients with dementia of the Alzheimer type.

Authors:  M E Appleyard; B McDonald
Journal:  J Neurol Neurosurg Psychiatry       Date:  1992-11       Impact factor: 10.154
  9 in total

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