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Literature DB >> 382571

The mutagenic activity of anti-cancer drugs and the urine of rats given these drugs.

K Pak, T Iwasaki, M Miyakawa, O Yoshida.

Abstract

Twenty-one anti-cancer drugs have been tested for their ability to cause mutations in Salmonella typhimurium test strains in the Salmonella/microsome mutagenicity test. Nine of the 21 anticancer drugs showed this ability: cyclophosphmide, nitromin, thio-tepa, busulfan, 6-mercaptopurine, neocarzinostatin, daunomycin, adriamycin and estramustine phosphate. Seven of these 9 mutagenic drugs were injected continuously into the jugular veins of rats. Urine was collected through a cystostomy tube and tested for mutagenicity. The urine from rats treated with 6 of these 7 drugs was mutagenic. These were cyclophosphamide, nitromin, thio-tepa, neocarzinostatin, adriamycin and daunomycin.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1979 PMID： 382571 DOI： 10.1007/bf00254692

Source DB: PubMed Journal: Urol Res ISSN： 0300-5623

21 in total

1. Experimental investigations with anti-cancer drugs for carcinogenicity with special reference to immunedepression.

Authors: D Schmähl
Journal: Recent Results Cancer Res Date: 1975

2. Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids.

Authors: J McCann; N E Spingarn; J Kobori; B N Ames
Journal: Proc Natl Acad Sci U S A Date: 1975-03 Impact factor: 11.205

3. The carcinogenic properties of some of the principal drugs used in clinical cancer chemotherapy.

Authors: J H Weisburger; D P Griswold; J D Prejean; A E Casey; H B Wood; E K Weisburger
Journal: Recent Results Cancer Res Date: 1975

4. Different incidence of breast carcinomas or fibroadenomas in daunomycin or adriamycin treated rats.

Authors: C Bertazzoli; T Chieli; E Solcia
Journal: Experientia Date: 1971-10-15

5. Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice.

Authors: G D Stoner; M B Shimkin; A J Kniazeff; J H Weisburger; E K Weisburger; G B Gori
Journal: Cancer Res Date: 1973-12 Impact factor: 12.701

6. Tumorigenicity in vivo and induction of malignant transformation and mutagenesis in cell cultures by adriamycin and daunomycin.

Authors: H Marquardt; F S Philips; S S Sternberg
Journal: Cancer Res Date: 1976-06 Impact factor: 12.701

The mutagenic activity of anti-cancer drugs and the urine of rats given these drugs.

1. Experimental investigations with anti-cancer drugs for carcinogenicity with special reference to immunedepression.

2. Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids.

3. The carcinogenic properties of some of the principal drugs used in clinical cancer chemotherapy.

4. Different incidence of breast carcinomas or fibroadenomas in daunomycin or adriamycin treated rats.

5. Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice.

6. Tumorigenicity in vivo and induction of malignant transformation and mutagenesis in cell cultures by adriamycin and daunomycin.

7. Mutagenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine, a bladder carcinogen, and related compounds.

8. A simple method for the detection of mutagens in urine: studies with the carcinogen 2-acetylaminofluorene.

9. Detection of mutagenic activity in human urine using mutant strains of Salmonella typhimurium.

Review 10. The carcinogenicity of anticancer drugs: a hazard in man.

1. The place of the host-mediated assay.

2. Mutagenicity of urine from nurses handling cytostatic drugs, influence of smoking.