Literature DB >> 3824710

Absorption of Adriamycin into the systemic circulation after intravesical instillation with or without Tween 80 in the rat.

S Hellsten, S Eksborg, B Axelsson.   

Abstract

The absorption of Adriamycin (ADM) into the systemic circulation after intravesical administration, using an experimental model in the rat, was closely related to the volume of the instilled solution and the concentration of the drug. The post instillation plasma concentration of ADM was increased after addition of Tween 80 to the instilled solution but the magnitude of the absorption was still discreet and, from a clinical point of view, negligible.

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Year:  1987        PMID： 3824710     DOI： 10.1007/bf00256330

Source DB:  PubMed          Journal:  Urol Res        ISSN： 0300-5623


  18 in total

1.  The management of superficial bladder tumours with intravesical Epodyl.

Authors:  P R Riddle
Journal:  Br J Urol       Date:  1973-02

2.  The effect of mitomycin C on superficial bladder cancer.

Authors:  M S Soloway; W M Murphy; M D DeFuria; S Crooke; P Finebaum
Journal:  J Urol       Date:  1981-05       Impact factor: 7.450

3.  Studies on the intravesical action of topically administered G3H-doxorubicin hydrochloride in men: plasma uptake and tumor penetration.

Authors:  G H Jacobi; K H Kurth
Journal:  J Urol       Date:  1980-07       Impact factor: 7.450

4.  Intravesical adriamycin therapy in carcinoma in situ of the urinary bladder.

Authors:  A Ek; S Hellsten; H Henrikson; I Idwall; C E Lindholm; K Lindholm; P Mikulowski; W Månsson
Journal:  Scand J Urol Nephrol       Date:  1984

5.  Reversed-phase liquid chromatographic determination of plasma levels of adriamycin and adriamycinol.

Authors:  S Eksborg; H Ehrsson; I Andersson
Journal:  J Chromatogr       Date:  1979-12-01

6.  Intravesical therapy of noninvasive bladder tumors (stage Ta) with doxorubicin and urokinase.

Authors:  F Lundbeck; P Mogensen; N Jeppesen
Journal:  J Urol       Date:  1983-12       Impact factor: 7.450

7.  Does intravesical chemotherapy prevent invasive bladder cancer?

Authors:  D F Green; M R Robinson; R Glashan; D Newling; O Dalesio; P H Smith
Journal:  J Urol       Date:  1984-01       Impact factor: 7.450

8.  Intravesical instillation of Adriamycin early after transurethral resection: measurements of plasma levels.

Authors:  A Larson; S Eksborg; A Fritjofsson
Journal:  Eur Urol       Date:  1984       Impact factor: 20.096

9.  Mitomycin instillation to prevent recurrence of superficial bladder carcinoma. Results of a controlled, prospective study in 58 patients.

Authors:  H Huland; U Otto
Journal:  Eur Urol       Date:  1983       Impact factor: 20.096

10.  Rapid absorption from the urinary bladder of a series of n-alkyl carbamates: a route for the recirculation of drugs.

Authors:  J W Bridges; N S Sargent; D G Upshall
Journal:  Br J Pharmacol       Date:  1979-06       Impact factor: 8.739
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  2 in total

1.  ThioTEPA pharmacokinetics during intravesical chemotherapy and the influence of Tween 80.

Authors:  J R Masters; B J McDermott; W E Jenkins; E Fenwick; P J Shah; A R Mundy; P M Loadman; M C Bibby
Journal:  Cancer Chemother Pharmacol       Date:  1990       Impact factor: 3.333

2.  Organ distribution of Adriamycin after intravesical instillation with or without Tween 80 in the rat.

Authors:  S Hellsten; B Axelsson; S Eksborg; C Lindkvist
Journal:  Urol Res       Date:  1988
  2 in total

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