Pregnancy outcome in mothers with cystic fibrosis: normal neonatal immune responses.

Although pregnancy with cystic fibrosis (CF) has been associated in previous reports with increased maternal and neonatal morbidity, this may not reflect the current outcome with intense perinatal medical support. This report describes the pregnancy and pregnancy outcome in four women with CF. Although one neonate was delivered prematurely to a mother with advanced CF, there were no developmental abnormalities. The one premature infant was appropriately developed for his gestational age. Maternal pulmonary function was not clearly influenced by pregnancy, as confirmed by similar Schwachman scores before conception and after delivery. Finally, in this series of patients the postdelivery Schwachman score could be predicted from the preconception score.