Literature DB >> 3822251

A disorder of cortical GABAergic innervation in Alzheimer's disease.

J Hardy, R Cowburn, A Barton, G Reynolds, P Dodd, P Wester, A M O'Carroll, E Lofdahl, B Winblad.   

Abstract

Synaptosomal gamma-aminobutyric acid (GABA) uptake has been used as a biochemical marker for GABAergic terminals in controls and Alzheimer disease brains. Use of this marker suggests a large (ca. 70%) loss of cortical and hippocampal GABA terminals in Alzheimer brain. To explain this observation we suggest that neuron loss in this disorder occurs via a process of cortical retrograde degeneration. This scheme reconciles our findings with previous neurochemical measurements on Alzheimer disease brains and also better reconciles the biochemistry with the histology of the disorder.

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Year:  1987        PMID： 3822251     DOI： 10.1016/0304-3940(87)90016-4

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  21 in total

Review 1.  Behavioural problems associated with dementia: the role of newer antipsychotics.

Authors:  G Stoppe; C A Brandt; J H Staedt
Journal:  Drugs Aging       Date:  1999-01       Impact factor: 3.923

2.  Can gabapentin be a safe alternative to hormonal therapy in the treatment of inappropriate sexual behavior in demented patients?

Authors:  Chadi Alkhalil; Nillay Hahar; Bachar Alkhalil; George Zavros; David T Lowenthal
Journal:  Int Urol Nephrol       Date:  2003       Impact factor: 2.370

Review 3.  Potential of GABA-ergic cell therapy for schizophrenia, neuropathic pain, and Alzheimer's and Parkinson's diseases.

Authors:  Ashok K Shetty; Adrian Bates
Journal:  Brain Res       Date:  2015-09-28       Impact factor: 3.252

4.  Postmortem- and cryostability of the potassium-evoked release of [3H]5-hydroxytryptamine from rat cerebral cortical miniprisms.

Authors:  C J Fowler; G Thorell; I Fagervall
Journal:  J Neural Transm       Date:  1989       Impact factor: 3.575

5.  Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice.

Authors:  Johanna Knoferle; Seo Yeon Yoon; David Walker; Laura Leung; Anna K Gillespie; Leslie M Tong; Nga Bien-Ly; Yadong Huang
Journal:  J Neurosci       Date:  2014-10-15       Impact factor: 6.167

6.  Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.

Authors:  Yaisa Andrews-Zwilling; Nga Bien-Ly; Qin Xu; Gang Li; Aubrey Bernardo; Seo Yeon Yoon; Daniel Zwilling; Tonya Xue Yan; Ligong Chen; Yadong Huang
Journal:  J Neurosci       Date:  2010-10-13       Impact factor: 6.167

Review 7.  Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.

Authors:  Yadong Huang; Robert W Mahley
Journal:  Neurobiol Dis       Date:  2014-08-27       Impact factor: 5.996

8.  Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Aβ accumulation.

Authors:  Leslie M Tong; Biljana Djukic; Christine Arnold; Anna K Gillespie; Seo Yeon Yoon; Max M Wang; Olivia Zhang; Johanna Knoferle; John L R Rubenstein; Arturo Alvarez-Buylla; Yadong Huang
Journal:  J Neurosci       Date:  2014-07-16       Impact factor: 6.167

9.  Loss of cortical GABA uptake sites in Alzheimer's disease.

Authors:  M D Simpson; A J Cross; P Slater; J F Deakin
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575

10.  Excitability and synaptic alterations in the cerebellum of APP/PS1 mice.

Authors:  Eriola Hoxha; Enrica Boda; Francesca Montarolo; Roberta Parolisi; Filippo Tempia
Journal:  PLoS One       Date:  2012-04-12       Impact factor: 3.240
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