| Literature DB >> 3822235 |
T Sharp, T Zetterström, L Christmanson, U Ungerstedt.
Abstract
The effect of p-chloroamphetamine (PCA) on extracellular levels of endogenous 5-hydroxytryptamine (5-HT) and dopamine (DA) in the striatum and frontal cortex of the halothane-anesthetized rat was studied using an intracerebral dialysis method. PCA (5 mg/kg s.c.) induced an immediate, marked release of 5-HT into dialysates collected from the frontal cortex and striatum, an effect which lasted over 2 h. This treatment also caused a marked release of DA in the striatum. The results further emphasize the need to carefully assess the involvement of brain DA as well as 5-HT in PCA-induced behaviors.Entities:
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Year: 1986 PMID： 3822235 DOI： 10.1016/0304-3940(86)90534-3
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046