Literature DB >> 3822050

D-pipecolic acid inhibits ethanol tolerance in mice.

G Szabó, G L Kovács, L Baláspiri, G Telegdy.   

Abstract

The effects of graded doses of D-pipecolic acid (0.005-5 micrograms/animals s.c.) on tolerance to the hypothermic effect of ethanol (4 g/kg i.p.) were investigated in mice. D-Pipecolic acid itself did not change the core temperature or the acute hypothermic response to a single dose of ethanol. Repeated D-pipecolic acid administration, however, blocked the development of tolerance to the hypothermic effect of ethanol. The development of tolerance could be observed in the control group. It is assumed that D-pipecolic acid is capable of counteracting the tolerance effect of ethanol.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3822050     DOI： 10.1007/bf00967746

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  13 in total

1.  Rapid development of tolerance to the hypothermic effect of ethanol in mice.

Authors:  J C Crabbe; H Rigter; J Uijlen; C Strijbos
Journal:  J Pharmacol Exp Ther       Date:  1979-01       Impact factor: 4.030

2.  Commentary on ethanol tolerance.

Authors:  B Tabakoff; C L Melchior; P L Hoffman
Journal:  Alcohol Clin Exp Res       Date:  1982       Impact factor: 3.455

3.  A calcium-dependent, high potassium-induced release of pipecolic acid from rat brain slices.

Authors:  Y Nomura; Y Okuma; T Segawa; T Schmidt-Glenewinkel; E G Giacobini
Journal:  J Neurochem       Date:  1979-09       Impact factor: 5.372

4.  Hyperpipecolic acidemia associated with hepatomegaly, mental retardation, optic nerve dysplasia and progressive neurological disease.

Authors:  G H Thomas; R H Haslam; M L Batshaw; A J Capute; L Neidengard; J L Ransom
Journal:  Clin Genet       Date:  1975-11       Impact factor: 4.438

5.  Pipecolic acid: a new type of alpha-amino acid possessing bicuculline-sensitive action in the mammalian brain.

Authors:  K Takahama; T Miyata; T Hashimoto; Y Okano; T Hitoshi; Y Kasé
Journal:  Brain Res       Date:  1982-05-06       Impact factor: 3.252

6.  Quantitative determination and regional distribution of pipecolic acid in rodent brain.

Authors:  J S Kim; E Giacobini
Journal:  Neurochem Res       Date:  1984-11       Impact factor: 3.996

7.  The effects of neurohypophyseal hormones on tolerance to the hypothermic effect of ethanol.

Authors:  G Szabó; G L Kovács; S Székeli; G Telegdy
Journal:  Alcohol       Date:  1985 Jul-Aug       Impact factor: 2.405

8.  Oxytocin and a C-terminal derivative (Z-prolyl-D-leucine) attenuate tolerance to and dependence on morphine and interact with dopaminergic neurotransmission in the mouse brain.

Authors:  G L Kovács; Z Horváth; Z Sarnyai; M Faludi; G Telegdy
Journal:  Neuropharmacology       Date:  1985-05       Impact factor: 5.250

9.  Uptake of piperidine and pipecolic acid by synaptosomes from mouse brain.

Authors:  Y Nomura; T Schmidt-Glenewinkel; E Giacobini
Journal:  Neurochem Res       Date:  1980-11       Impact factor: 3.996

10.  Effect on brain monoamines in the rat of substituted and protected analogues of the oxytocin fragment, prolyl-leucyl-glycinamide following N-terminal substitution by D- and L-pipecolic acid.

Authors:  G Szabó; G L Kovács; L Baláspiri; G Telegdy
Journal:  Acta Physiol Hung       Date:  1986
View more
  1 in total

1.  High-affinity binding of proline to mouse brain synaptic membranes.

Authors:  J G Ortiz; A E Negrón; M S Bruno
Journal:  Neurochem Res       Date:  1989-02       Impact factor: 3.996
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.