Literature DB >> 3821919

Therapeutic application of radiolabeled monoclonal antibody UJ13A in children with disseminated neuroblastoma.

L Lashford, D Jones, J Pritchard, I Gordon, F Breatnach, J T Kemshead.   

Abstract

Dosimetric data from UJ13A scanning studies using 131I are presented for children with stage IV neuroblastoma and primary brain tumor. The data demonstrate a large variation among patients in dose delivery to vulnerable organs and tumors. Against this background, a phase I toxicity study is under way with escalating amounts of conjugate administered to patients who have stage IV neuroblastoma. Major toxicity has been confined to bone marrow aplasia and necessitates bone marrow harvest prior to therapy. Specific problems encountered include altered kinetics during therapy following tracer studies and adequate dose delivery in large tumor masses.

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Year:  1987        PMID： 3821919

Source DB:  PubMed          Journal:  NCI Monogr        ISSN： 0893-2751


  8 in total

1.  Dosimetry of intrathecal iodine131 monoclonal antibody in cases of neoplastic meningitis.

Authors:  R B Richardson; J T Kemshead; A G Davies; G E Staddon; P C Jackson; H B Coakham; L S Lashford
Journal:  Eur J Nucl Med       Date:  1990

2.  Radioimmunotherapy: no news from the newcomer.

Authors:  A M Mello; E K Pauwels; F J Cleton
Journal:  J Cancer Res Clin Oncol       Date:  1994       Impact factor: 4.553

3.  Ablation of human colon carcinoma in nude mice by 131I-labeled monoclonal anti-carcinoembryonic antigen antibody F(ab')2 fragments.

Authors:  F Buchegger; C Pfister; K Fournier; F Prevel; M Schreyer; S Carrel; J P Mach
Journal:  J Clin Invest       Date:  1989-05       Impact factor: 14.808

4.  Radioimmunotherapy of small-cell lung cancer xenografts using 131I-labelled anti-NCAM monoclonal antibody 123C3.

Authors:  H B Kwa; A H Verhoeven; J Storm; N van Zandwijk; W J Mooi; J Hilkens
Journal:  Cancer Immunol Immunother       Date:  1995-09       Impact factor: 6.968

5.  Potentiation of a weakly active ricin A chain immunotoxin recognizing the neural cell adhesion molecule.

Authors:  E J Derbyshire; R A Stahel; E J Wawrzynczak
Journal:  Clin Exp Immunol       Date:  1992-09       Impact factor: 4.330

6.  Doxorubicin conjugated with a monoclonal antibody directed to a human melanoma-associated proteoglycan suppresses the growth of established tumor xenografts in nude mice.

Authors:  H M Yang; R A Reisfeld
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

7.  Radioimmunotherapy of transplanted small cell lung cancer with 131I-labelled monoclonal antibody.

Authors:  S Yoneda; M Fujisawa; J Watanabe; T Okabe; F Takaku; T Homma; K Yoshida
Journal:  Br J Cancer       Date:  1988-09       Impact factor: 7.640

8.  Immunoscintigraphy of small-cell lung cancer xenografts with anti neural cell adhesion molecule monoclonal antibody, 123C3: improvement of tumour uptake by internalisation.

Authors:  H B Kwa; J Wesseling; A H Verhoeven; N van Zandwijk; J Hilkens
Journal:  Br J Cancer       Date:  1996-02       Impact factor: 7.640
  8 in total

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