Literature DB >> 382155

A multicentre pilot study of parenteral and rectal administration of domperidone in the treatment of severe vomiting in children.

R Clara, J Van Hollebeke, E Heck.   

Abstract

A small scale pilot study among 41 children with severe vomiting, showed that a single administration of domperidone either intravenously, intramuscularly or rectally, effectively controlled the symptom within 3 hours in 36 (88%) patients. The excellent results together with the safety of this new drug indicate its potential value in these patients.

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Year:  1979        PMID： 382155

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN： 0032-5473            Impact factor:   2.401


  3 in total

1.  On the pharmacokinetics of domperidone in animals and man. IV. The pharmacokinetics of intravenous domperidone and its bioavailability in man following intramuscular, oral and rectal administration.

Authors:  J Heykants; R Hendriks; W Meuldermans; M Michiels; H Scheygrond; H Reyntjens
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1981       Impact factor: 2.441

2.  Domperidone as an antiemetic in paediatric oncology.

Authors:  A O'Meara; M G Mott
Journal:  Cancer Chemother Pharmacol       Date:  1981       Impact factor: 3.333

Review 3.  Domperidone. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic.

Authors:  R N Brogden; A A Carmine; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1982-11       Impact factor: 9.546
  3 in total

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