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Literature DB >> 382151

Domperidone in the treatment of functional dyspepsia in patients with delayed gastric emptying.

Abstract

Forty patients who were suffering from chronic dyspepsia, diagnosed clinically and radiologically as being related to delayed gastric emptying, were treated with either domperidone or placebo in a double-blind trial. The trial lasted four weeks and the dose of domperidone was 10 mg orally t.d.s. before meals. The results showed that the drug markedly improved symptoms and that side effects were few, being recorded in one patient only, on active treatment. It is concluded that domperidone is a useful agent for the treatment of dyspepsia with retarded gastric emptying.

Entities: Chemical Disease Species

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Year: 1979 PMID： 382151

Source DB: PubMed Journal: Postgrad Med J ISSN： 0032-5473 Impact factor: 2.401

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Cited

11 in total

Review 1. ACG and CAG Clinical Guideline: Management of Dyspepsia.

Authors: Paul Moayyedi; Brian E Lacy; Christopher N Andrews; Robert A Enns; Colin W Howden; Nimish Vakil
Journal: Am J Gastroenterol Date: 2017-06-20 Impact factor: 10.864

Review 2. Dyspepsia and its overlap with irritable bowel syndrome.

Authors: William M Outlaw; Kenneth L Koch
Journal: Curr Gastroenterol Rep Date: 2006-08

3. On the pharmacokinetics of domperidone in animals and man. IV. The pharmacokinetics of intravenous domperidone and its bioavailability in man following intramuscular, oral and rectal administration.

Authors: J Heykants; R Hendriks; W Meuldermans; M Michiels; H Scheygrond; H Reyntjens
Journal: Eur J Drug Metab Pharmacokinet Date: 1981 Impact factor: 2.441

Review 4. Functional dyspepsia. Current treatment recommendations.

Authors: Gerald Holtmann; Nicholas J Talley
Journal: Drugs Date: 1993-06 Impact factor: 9.546

Review 5. Domperidone. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic.

Authors: R N Brogden; A A Carmine; R C Heel; T M Speight; G S Avery
Journal: Drugs Date: 1982-11 Impact factor: 9.546

6. Comparative Efficacy of Various Pharmacological Interventions in the Treatment of Functional Dyspepsia: A Network Meta-Analysis.

Authors: Liang Liang; Jia Yu; Ling Xiao; Gaohua Wang
Journal: Dig Dis Sci Date: 2021-02-15 Impact factor: 3.199

Domperidone in the treatment of functional dyspepsia in patients with delayed gastric emptying.

Review 1. ACG and CAG Clinical Guideline: Management of Dyspepsia.

Review 2. Dyspepsia and its overlap with irritable bowel syndrome.

3. On the pharmacokinetics of domperidone in animals and man. IV. The pharmacokinetics of intravenous domperidone and its bioavailability in man following intramuscular, oral and rectal administration.

Review 4. Functional dyspepsia. Current treatment recommendations.

Review 5. Domperidone. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic.

6. Comparative Efficacy of Various Pharmacological Interventions in the Treatment of Functional Dyspepsia: A Network Meta-Analysis.

Review 7. Optimal management of patients with non-ulcer dyspepsia: considerations for the treatment of the elderly.

Review 8. Proton pump inhibitors for functional dyspepsia.

9. Saudi Gastroenterology Association position statement on safety issues associated with the use of domperidone.

10. Prokinetics for functional dyspepsia.