Literature DB >> 3821169

Studies on tumor necrosis factor (TNF): II. Metabolic fate and distribution of human recombinant TNF.

G P Pessina, A Pacini, V Bocci, E Maioli, A Naldini.   

Abstract

We have evaluated the fate of cold and 125I- human recombinant tumor necrosis factor (RTNF) using isolated organs such as rabbit and monkey livers and rabbit kidney and lungs. We have also evaluated the body distribution of the total radioactivity after iv administration of 125I-RTNF in the rabbits. Monkey and rabbit livers play little catabolic role for RTNF. Lungs do not catabolize TNF at all, while the kidney appears to be the main catabolic organ. Accordingly, the body distribution of 125I-RTNF shows that most of the radioactivity is concentrated in the kidneys.

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Year:  1987        PMID： 3821169

Source DB:  PubMed          Journal:  Lymphokine Res        ISSN： 0277-6766


  8 in total

1.  Characterization and Interspecies Scaling of rhTNF-α Pharmacokinetics with Minimal Physiologically Based Pharmacokinetic Models.

Authors:  Xi Chen; Debra C DuBois; Richard R Almon; William J Jusko
Journal:  Drug Metab Dispos       Date:  2017-04-14       Impact factor: 3.922

Review 2.  Interleukins. Clinical pharmacokinetics and practical implications.

Authors:  V Bocci
Journal:  Clin Pharmacokinet       Date:  1991-10       Impact factor: 6.447

3.  Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity.

Authors:  Patrick J Shaw; Kevin M Beggs; Erica M Sparkenbaugh; Christine M Dugan; Patricia E Ganey; Robert A Roth
Journal:  Toxicol Sci       Date:  2009-07-28       Impact factor: 4.849

4.  Fractional excretion of tumor necrosis factor-alpha in women with severe preeclampsia.

Authors:  Michael Cackovic; Catalin S Buhimschi; Guomao Zhao; Edmund F Funai; Errol R Norwitz; Edward Kuczynski; Charles J Lockwood; Irina A Buhimschi
Journal:  Obstet Gynecol       Date:  2008-07       Impact factor: 7.661

5.  Inflammatory mediators release in urine from mice injected with Crotalus durissus terrificus venom.

Authors:  A Hernández Cruz; L Barbosa Navarro; R Z Mendonça; V L Petricevich
Journal:  Mediators Inflamm       Date:  2011-11-29       Impact factor: 4.711

6.  Chronic cigarette smoking enhances spontaneous release of tumour necrosis factor-alpha from alveolar macrophages of rats.

Authors:  G P Pessina; L Paulesu; F Corradeschi; E Luzzi; M Tanzini; C Aldinucci; A Di Stefano; V Bocci
Journal:  Mediators Inflamm       Date:  1993       Impact factor: 4.711

7.  Effects of acute cigarette smoke exposure on macrophage kinetics and release of tumour necrosis factor alpha in rats.

Authors:  G P Pessina; L Paulesu; F Corradeschi; E Luzzi; A D Stefano; M Tanzini; G Matteucci; V Bocci
Journal:  Mediators Inflamm       Date:  1993       Impact factor: 4.711

Review 8.  Tamm-Horsfall Protein is a Potent Immunomodulatory Molecule and a Disease Biomarker in the Urinary System.

Authors:  Tsai-Hung Wu; Ko-Jen Li; Chia-Li Yu; Chang-Youh Tsai
Journal:  Molecules       Date:  2018-01-22       Impact factor: 4.411
  8 in total

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