| Literature DB >> 3820295 |
Abstract
The importance of the polymorphism of DNA in the reaction with the chemical carcinogen N-hydroxyaminofluorene is studied by means of a supercoiled plasmid containing an insert of (dC-dG). Immunochemical titration and the determination of the binding spectrum of -aminofluorene adducts show that the carcinogen reacts with B-DNA but not with Z-DNA and that conformational changes of the B-DNA-Z-DNA junctions occur as a function of the superhelical density.Entities:
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Year: 1986 PMID： 3820295 DOI： 10.1016/0022-2836(86)90149-x
Source DB: PubMed Journal: J Mol Biol ISSN： 0022-2836 Impact factor: 5.469