| Literature DB >> 3820231 |
K H Lee, G K Rice, I H Hall, V Amarnath.
Abstract
alpha-Methylene-gamma-lactones covalently linked to adenine, hypoxanthine, and guanine were synthesized by using the convenient Reformatsky-type reaction between ethyl alpha-(bromomethyl)acrylate and the proper purine ketones. In vitro cytotoxicity data demonstrated that these compounds were active against L-1210 tissue culture cells with 3 being most potent (ED50 = 0.3 microgram/mL).Entities:
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Year: 1987 PMID： 3820231 DOI： 10.1021/jm00386a025
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446