Literature DB >> 3818562

The regulation by growth hormone of microsomal testosterone 6 beta-hydroxylase in male rat livers.

Y Yamazoe, M Shimada, N Murayama, S Kawano, R Kato.   

Abstract

The relationship between growth hormone and testosterone (T) 6 beta-hydroxylase was investigated in normal and hypophysectomized (hypox) male rats. The administration of human growth hormone (hGH) by either intermittent injections or continuous infusion to normal and hypox rats decreased the activity of T 6 beta-hydroxylase in hepatic microsomes. Hypophysectomy did not reduce, but rather increased the 6 beta-hydroxylase activity, while the 16 alpha-hydroxylase activity decreased. These results, together with the data from a Western blot, indicate that growth hormone acts as a repressive factor for the expression of T 6 beta-hydroxylase in a manner different from the regulation of T 16 alpha-hydroxylase.

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Year:  1986        PMID： 3818562     DOI： 10.1093/oxfordjournals.jbchem.a121790

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  6 in total

1.  Influence of growth hormone on the hepatic mixed function oxidase and transferase systems of rainbow trout.

Authors:  J P Cravedi; A Paris; E Perdu-Durand; P Prunet
Journal:  Fish Physiol Biochem       Date:  1995-08       Impact factor: 2.794

2.  Hormonal regulation of the zonated expression of cytochrome P-450 3A in rat liver.

Authors:  T Oinonen; K O Lindros
Journal:  Biochem J       Date:  1995-07-01       Impact factor: 3.857

3.  Dioxin-induced fetal growth retardation: the role of a preceding attenuation in the circulating level of glucocorticoid.

Authors:  Yukiko Hattori; Tomoki Takeda; Misaki Fujii; Junki Taura; Yuji Ishii; Hideyuki Yamada
Journal:  Endocrine       Date:  2014-04-11       Impact factor: 3.633

Review 4.  Sex differences in the expression of hepatic drug metabolizing enzymes.

Authors:  David J Waxman; Minita G Holloway
Journal:  Mol Pharmacol       Date:  2009-05-29       Impact factor: 4.436

5.  Metabolism of cyclosporine by cytochromes P450 3A9 and 3A4.

Authors:  P A Kelly; H Wang; K L Napoli; B D Kahan; H W Strobel
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1999 Oct-Dec       Impact factor: 2.569

6.  Decrease in the metabolic activating capacities of arylamines in livers bearing hyperplastic nodules: association with the selective changes in hepatic P-450 isozymes.

Authors:  S Ozawa; M Abu-Zeid; N Murayama; Y Yamazoe; R Kato
Journal:  Jpn J Cancer Res       Date:  1990-03
  6 in total

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