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Literature DB >> 3818504

The comparative study of cardiovascular toxins utilizing a sensitive indicator of sublethal toxic injury.

Abstract

This study measures the inhibition of [3H]uridine uptake by smooth muscle cells to determine sublethal toxic injury by the cardiovascular toxins, allylamine, isoproterenol, and beta-aminopropionitrile. The exposure period or the concentration of toxin which inhibited 30% of [3H]uridine uptake by smooth muscle cells could be utilized as an endpoint for ranking toxicity. Cytotoxicity of the three toxins to smooth muscle cells were ranked as: allylamine greater than isoproterenol greater than beta-aminopropionitrile. Recovery of cells utilizing [3H]uridine uptake inhibition as a method for assessing comparative cytotoxicity and for screening of agents potentially injurious to vascular cells.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1987 PMID： 3818504 DOI： 10.1007/bf02623593

Source DB: PubMed Journal: In Vitro Cell Dev Biol ISSN： 0883-8364

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References

17 in total

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Authors: D G Wenzel; G N Cosma
Journal: Toxicology Date: 1984-11 Impact factor: 4.221

The comparative study of cardiovascular toxins utilizing a sensitive indicator of sublethal toxic injury.

1. Determination of toxin-induced leakage of different-size nucleotides through the plasma membrane of human diploid fibroblasts.

2. Uptake of nucleosides in density-inhibited cultures of 3T3 cells.

3. Studies on the mechanism of lymphocyte-mediated cytolysis. II. The use of various target cell markers to study cytolytic events.

4. An in vitro approach to the study of target organ toxicity of drugs and chemicals.

5. The response of isolated rat heart cells to cardiotoxic concentrations of isoprenaline.

6. What controls smooth muscle phenotype?

7. Ultrastructural alterations in allylamine cardiovascular toxicity. Late myocardial and vascular lesions.

8. Ultrastructural alterations in allylamine- induced cardiomyopathy: early lesions.

9. Myocardial fibrosis and smooth muscle cell hyperplasia in coronary arteries of allylamine-fed rats.

10. A model system for measuring comparative toxicities of cardiotoxic drugs with cultured rat heart myocytes, endothelial cells and fibroblasts. I. Emetine, chloroquine and metronidazole.