Literature DB >> 3817107

Inhibition of cadmium teratogenesis by a mercaptoacrylic acid (MFA).

V H Ferm, D P Hanlon.   

Abstract

The teratogenic effect of cadmium can be diminished by a number of mechanisms including zinc and pretreatment with cadmium and mercury. In this study, the oral administration of alpha-mercapto-beta-(2-furyl)-acrylic acid (MFA) protects against cadmium-induced malformations and embryonic death. This protection is probably mediated by the chelation of the cadmium ion rather than metallothionein (MT) synthesis.

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Year:  1987        PMID： 3817107     DOI： 10.1007/bf01942856

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  The relationship of cadmium and zinc in experimental mammalian teratogenesis.

Authors:  V H Ferm; S J Carpenter
Journal:  Lab Invest       Date:  1968-04       Impact factor: 5.662

2.  Reduction in cadmium teratogenesis by prior cadmium expsoure.

Authors:  V H Ferm; W M Layton
Journal:  Environ Res       Date:  1979-04       Impact factor: 6.498

3.  The chemical status of cadmium ion in the placenta.

Authors:  D P Hanlon; C Specht; V H Ferm
Journal:  Environ Res       Date:  1982-02       Impact factor: 6.498

4.  Protection against cadmium-induced limb malformations by pretreatment with cadmium or mercury.

Authors:  W M Layton; V H Ferm
Journal:  Teratology       Date:  1980-06

5.  Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues.

Authors:  D L Eaton; B F Toal
Journal:  Toxicol Appl Pharmacol       Date:  1982-10       Impact factor: 4.219

6.  Developmental malformations induced by cadmium. A study of timed injections during embryogenesis.

Authors:  V H Ferm
Journal:  Biol Neonate       Date:  1971

7.  Kidney and liver metallothioneins in rats after administration of an organic compound.

Authors:  E Giroux; P J Lachmann
Journal:  J Biol Chem       Date:  1984-03-25       Impact factor: 5.157

8.  Teratogenic effects of ribavirin on hamster and rat embryos.

Authors:  V H Ferm; C Willhite; L Kilham
Journal:  Teratology       Date:  1978-02

9.  Quantification of metallothioneins by a silver-saturation method.

Authors:  A M Scheuhammer; M G Cherian
Journal:  Toxicol Appl Pharmacol       Date:  1986-03-15       Impact factor: 4.219

10.  Teratogenic dose-response relationships of etretinate in the golden hamster.

Authors:  K J Williams; V H Ferm; C C Willhite
Journal:  Fundam Appl Toxicol       Date:  1984-12
  10 in total

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