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Literature DB >> 3816966

Bradykinin inhibits a slow spike afterhyperpolarization in visceral sensory neurons.

Abstract

Intracellular recordings were made from visceral sensory neurons in vitro. Bradykinin (BK) depressed a slow Ca2+-activated K+-dependent (KCa) spike afterhyperpolarization (AHPs) in the range of 0.2-1 nM. BK did not affect the fast KCa spike afterhyperpolarization preceding the AHPs or the action potential waveform. Indomethacin pretreatment abolished the BK effect. These results indicate that BK can influence the excitability of vagal afferent neurons.

Entities: Chemical Gene

Mesh：

Substances：
Bradykinin
Indomethacin

Year: 1986 PMID： 3816966 DOI： 10.1016/0014-2999(86)90010-5

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

11 in total

1. Effects of phorbol dibutyrate on M currents and M current inhibition in bullfrog sympathetic neurons.

Authors: D A Brown; P R Adams
Journal: Cell Mol Neurobiol Date: 1987-09 Impact factor: 5.046

2. 5HT4 receptors couple positively to tetrodotoxin-insensitive sodium channels in a subpopulation of capsaicin-sensitive rat sensory neurons.

Authors: C G Cardenas; L P Del Mar; B Y Cooper; R S Scroggs
Journal: J Neurosci Date: 1997-10-01 Impact factor: 6.167

3. Histamine H1 receptor activation blocks two classes of potassium current, IK(rest) and IAHP, to excite ferret vagal afferents.

Authors: M S Jafri; K A Moore; G E Taylor; D Weinreich
Journal: J Physiol Date: 1997-09-15 Impact factor: 5.182

4. Bradykinin-induced activation of nociceptors: receptor and mechanistic studies on the neonatal rat spinal cord-tail preparation in vitro.

Authors: A Dray; I A Patel; M N Perkins; A Rueff
Journal: Br J Pharmacol Date: 1992-12 Impact factor: 8.739

5. Inhibition of calcium-dependent spike after-hyperpolarization increases excitability of rabbit visceral sensory neurones.

Authors: D Weinreich; W F Wonderlin
Journal: J Physiol Date: 1987-12 Impact factor: 5.182

6. Effect of bradykinin and prostaglandins on the release of calcitonin gene-related peptide-like immunoreactivity from the rat spinal cord in vitro.

Authors: L Andreeva; H P Rang
Journal: Br J Pharmacol Date: 1993-01 Impact factor: 8.739

7. Prevention of the excitatory actions of bradykinin by inhibition of PGI2 formation in nodose neurones of the guinea-pig.

Authors: D Weinreich; G M Koschorke; B J Undem; G E Taylor
Journal: J Physiol Date: 1995-03-15 Impact factor: 5.182