| Literature DB >> 3816959 |
P C Wong, C J Keirans, P B Timmermans.
Abstract
In the rabbit ear artery, nifedipine, verapamil, diltiazem and bepridil were found to be more potent in inhibiting the tonic than the phasic response to norepinephrine, while KB-944 and W-7 blocked these two responses equally. Since in the ear artery norepinephrine utilizes intracellular and extracellular Ca2+ for its phasic and tonic responses, respectively, the non-selective inhibitory effect of KB-944 suggests that Ca2+ entry blockade may not account solely for its vasodilator effect.Entities:
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Year: 1986 PMID： 3816959 DOI： 10.1016/0014-2999(86)90589-3
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432