Literature DB >> 3815727

Toxicity of 5-fluorouracil for aerobic and hypoxic cells in two murine tumours.

I F Tannock.   

Abstract

Chronically hypoxic cells in solid tumours are reported to be more slowly proliferating than aerobic cells situated closer to blood vessels. Cycle-active drugs such as 5-fluorouracil (5-FU) might be expected to have greater activity against rapidly proliferating aerobic cells. The effect of 5-FU was therefore assessed against aerobic and hypoxic cells in murine tumours; this was done by giving the drug alone or 1 h before irradiation of the tumour under aerobic or hypoxic conditions. Aerobic and hypoxic cells appeared to have equal sensitivity to 5-FU in the KHT and 16/C tumours, and the effect of a single dose of 5-FU was additive to that of radiation.

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Year:  1987        PMID： 3815727     DOI： 10.1007/bf00296256

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  20 in total

1.  The response of hypoxic B16 melanoma cells to in vivo treatment with chemotherapeutic agents.

Authors:  R P Hill; J A Stanley
Journal:  Cancer Res       Date:  1975-05       Impact factor: 12.701

2.  A new method of determining the fraction of hypoxic cells in a transplantable murine sarcoma.

Authors:  R P Hill; R S Bush
Journal:  Radiat Res       Date:  1977-04       Impact factor: 2.841

3.  Tumour cell proliferation in relation to the vasculature.

Authors:  D G Hirst; J Denekamp
Journal:  Cell Tissue Kinet       Date:  1979-01

4.  Population kinetics of carcinoma cells, capillary endothelial cells, and fibroblasts in a transplanted mouse mammary tumor.

Authors:  I F Tannock
Journal:  Cancer Res       Date:  1970-10       Impact factor: 12.701

Review 5.  Cell kinetics and chemotherapy: a critical review.

Authors:  I Tannock
Journal:  Cancer Treat Rep       Date:  1978-08

6.  Hyperbaric oxygen and radiobiology of a C3H mouse mammary carcinoma.

Authors:  H D Suit; M Maeda
Journal:  J Natl Cancer Inst       Date:  1967-10       Impact factor: 13.506

7.  Limited penetration of methotrexate into human osteosarcoma spheroids as a proposed model for solid tumor resistance to adjuvant chemotherapy.

Authors:  G W West; R Weichselbaum; J B Little
Journal:  Cancer Res       Date:  1980-10       Impact factor: 12.701

8.  Cell cycle specific toxicity of the Hoechst 33342 stain in untreated or irradiated murine tumor cells.

Authors:  D W Siemann; P C Keng
Journal:  Cancer Res       Date:  1986-07       Impact factor: 12.701

9.  Cell selection from a murine tumour using the fluorescent probe Hoechst 33342.

Authors:  D J Chaplin; R E Durand; P L Olive
Journal:  Br J Cancer       Date:  1985-04       Impact factor: 7.640

10.  Solid tumour models for the assessment of different treatment modalities: IV. the combined effects of radiation and 5-fluorouracil.

Authors:  W B Looney; J G Schaffner; J S Trefil; C J Kovacs; H A Hopkins
Journal:  Br J Cancer       Date:  1976-09       Impact factor: 7.640
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  2 in total

1.  Effect of etoposide, carmustine, vincristine, 5-fluorouracil, or methotrexate on radiobiologically oxic and hypoxic cells in a C3H mouse mammary carcinoma in situ.

Authors:  C Grau; J Overgaard
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

2.  The role of haemoglobin level in predicting the response to first-line chemotherapy in advanced colorectal cancer patients.

Authors:  M Tampellini; A Saini; I Alabiso; R Bitossi; M P Brizzi; C M Sculli; A Berruti; G Gorzegno; A Magnino; E Sperti; S Miraglia; L Forti; O Alabiso; M Aglietta; A Harris; L Dogliotti
Journal:  Br J Cancer       Date:  2006-06-13       Impact factor: 7.640
  2 in total

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