| Literature DB >> 3815325 |
G J Patskan, A J Klein-Szanto, J L Phillips, T J Slaga.
Abstract
The incidence of metastasis was evaluated in female SENCAR mice after induction of squamous cell carcinomas by repetitive applications of either benzo [a] pyrene (B [a] P) or N-methyl-N'-nitro-N-nitrosogaunidine (MNNG). Between 41 and 50 weeks 50% of the animals with carcinomas in the B [a] P group had metastases, whereas 20% had metastases in the MNNG group. Very few metastases were observed before 40 weeks of treatment. The major site of metastasis was the lungs; however, metastatic tumors were also found in lymph nodes, adrenal glands and kidneys.Entities:
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Year: 1987 PMID： 3815325 DOI： 10.1016/0304-3835(87)90002-4
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679