Literature DB >> 381515

Demonstration of phosphorylcholine-specific IgE B cells in CBA/N mice.

T Kishimoto, S Shigemoto, T Watanabe, Y Yamamura.   

Abstract

CBA/N mice, which did not make anti-PC IgM or IgG antibody against PC-conjugated T-dependent or T-independent antigens, produced IgE antibody to PC-determinant when they were immunized with PC-KLH. PC-specificity of IgE antibody produced in CBA/N mice was determined by inhibition of PCA reaction with free PC-hapten or C-polysaccharide or by absorption of reaginic activity in the serum with C-polysaccharide. The presence of T15 idiotype on anti-PC IgE antibody produced in CBA/N x BALB/c F1 males also showed that anti-PC IgE antibody in defective mice was PC-specific. The results suggest that PC-specific B epsilon cells may belong to a subpopulation distinct from PC-specific precursors for IgM and IgG responses.

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Year:  1979        PMID： 381515

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  7 in total

1.  Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3.

Authors:  Yuko Kawakami; Naoki Inagaki; Shahram Salek-Ardakani; Jiro Kitaura; Hiroyuki Tanaka; Koichi Nagao; Yu Kawakami; Wenbin Xiao; Hiroichi Nagai; Michael Croft; Toshiaki Kawakami
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-21       Impact factor: 11.205

2.  Immunogenic properties of octasaccharide-protein conjugates derived from Klebsiella serotype 11 capsular polysaccharide.

Authors:  J W Zigterman; J E van Dam; H Snippe; F T Rotteveel; M Jansze; J M Willers; J P Kamerling; J F Vliegenthart
Journal:  Infect Immun       Date:  1985-02       Impact factor: 3.441

3.  A clonal analysis of the IgE response and its implications with regard to isotope commitment.

Authors:  J M Teale; F T Liu; D H Katz
Journal:  J Exp Med       Date:  1981-04-01       Impact factor: 14.307

4.  Antibody-defective, genetically susceptible CBA/N mice have an altered Salmonella typhimurium-specific B cell repertoire.

Authors:  L W Duran; E S Metcalf
Journal:  J Exp Med       Date:  1987-01-01       Impact factor: 14.307

5.  Immune response to a thymus-dependent form of B512 dextran requires the presence of Lyb-5+ lymphocytes.

Authors:  K E Stein; D A Zopf; C B Miller; B M Johnson; P K Mongini; A Ahmed; W E Paul
Journal:  J Exp Med       Date:  1983-02-01       Impact factor: 14.307

6.  IgG subclass, IgE, and IgA anti-trinitrophenyl antibody production within trinitrophenyl-Ficoll-responsive B cell clones. Evidence in support of three distinct switching pathways.

Authors:  P K Mongini; W E Paul; E S Metcalf
Journal:  J Exp Med       Date:  1983-01-01       Impact factor: 14.307

7.  Mice with the xid defect have helper cells for T15 idiotype-dominant anti-phosphorylcholine primary and secondary plaque-forming cells responses.

Authors:  J Quintáns; Z S Quan; M A Arias
Journal:  J Exp Med       Date:  1982-04-01       Impact factor: 14.307
  7 in total

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