Literature DB >> 3815085

Denervation supersensitivity of 5-HT-1c receptors in rat choroid plexus.

P J Conn, A Janowsky, E Sanders-Bush.   

Abstract

Serotonin (5-HT)-stimulated phosphoinositide hydrolysis in the choroid plexus is mediated by the 5-HT-1c receptor. The current study demonstrates that treatment of rats with the serotonergic neurotoxin, 5,7-dihydroxytryptamine, caused a marked depletion of 5-HT and a supersensitive 5-HT-1c mediated phosphoinositide hydrolysis response. These data suggest that the 5-HT-1c site in choroid plexus receives tonic serotonergic input.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3815085     DOI： 10.1016/0006-8993(87)90641-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  5 in total

1.  Central serotonin receptors: effector systems, physiological roles and regulation.

Authors:  P J Conn; E Sanders-Bush
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

2.  Subchronic administration of para-chlorophenylalanine enhances serotonin-stimulated phosphoinositide hydrolysis in rat hippocampal slices.

Authors:  I Kusumi; M Mikuni; Y Kuroda; K Takahashi
Journal:  J Neural Transm Gen Sect       Date:  1990

3.  The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. III: The mechanistic basis for supersensitivity to the LSD stimulus following serotonin depletion.

Authors:  D Fiorella; S Helsley; D S Lorrain; R A Rabin; J C Winter
Journal:  Psychopharmacology (Berl)       Date:  1995-10       Impact factor: 4.530

Review 4.  Phosphoinositide system-linked serotonin receptor subtypes and their pharmacological properties and clinical correlates.

Authors:  S C Pandey; J M Davis; G N Pandey
Journal:  J Psychiatry Neurosci       Date:  1995-05       Impact factor: 6.186

5.  Insulin signaling inhibits the 5-HT2C receptor in choroid plexus via MAP kinase.

Authors:  Joyce H Hurley; Shengwen Zhang; Leighan S Bye; Mark S Marshall; Anna A DePaoli-Roach; Kunliang Guan; Aaron P Fox; Lei Yu
Journal:  BMC Neurosci       Date:  2003-06-09       Impact factor: 3.288
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.