Literature DB >> 3814110

Characterization of the synaptosomal high-affinity uptake of noradrenaline in the nucleus accumbens of rats.

L Hetey, B Zimmermann.   

Abstract

In the nucleus (n.) accumbens, a predominantly dopaminergic innervated brain region, a high-affinity noradrenaline (NA) uptake exists indicating NA termination in this area. The affinity of the uptake carrier (Km) is in the range of that given for other regions. For characterizing the specificity of NA uptake, inhibitory experiments of NA and dopamine (DA) uptake were carried out with nomifensine and desipramine. The experiments with desipramine clearly show that the NA uptake is independent of the DA uptake into dopaminergic terminals occurring predominantly in this nucleus.

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Year:  1986        PMID： 3814110

Source DB:  PubMed          Journal:  Biomed Biochim Acta        ISSN： 0232-766X


  8 in total

1.  Lack of interaction between alpha 2-adrenoceptors and dopamine D2-receptors in mediating their inhibitory effects on [3H]dopamine release from rat nucleus accumbens slices.

Authors:  V A Russell; M C Lamm; J J Taljaard
Journal:  Neurochem Res       Date:  1993-03       Impact factor: 3.996

2.  Increased dopamine D2 receptor-mediated inhibition of [14C]acetylcholine release in the dorsomedial part of the nucleus accumbens.

Authors:  V A Russell; R Allin; M C Lamm; J J Taljaard
Journal:  Neurochem Res       Date:  1989-09       Impact factor: 3.996

3.  Effect of selective noradrenergic denervation on noradrenaline content and [3H]dopamine release in rat nucleus accumbens slices.

Authors:  V A Russell; M C Lamm; R Allin; A S de Villiers; A Searson; J J Taljaard
Journal:  Neurochem Res       Date:  1989-02       Impact factor: 3.996

4.  Studies in postmortem dopamine uptake. II. Alterations of the synaptosomal catecholamine uptake in postmortem brain regions in schizophrenia.

Authors:  N Haberland; L Hetey
Journal:  J Neural Transm       Date:  1987       Impact factor: 3.575

5.  Studies in postmortem dopamine uptake. I. Kinetic characterization of the synaptosomal dopamine uptake in rat and human brain after postmortem storage and cryopreservation. Comparison with noradrenaline and serotonin uptake.

Authors:  N Haberland; L Hetey
Journal:  J Neural Transm       Date:  1987       Impact factor: 3.575

6.  Regional distribution of monoamines in the nucleus accumbens of the rat.

Authors:  R Allin; V A Russell; M C Lamm; J J Taljaard
Journal:  Neurochem Res       Date:  1988-10       Impact factor: 3.996

7.  Role of alpha adrenoceptors in the nucleus accumbens in the control of accumbal noradrenaline efflux: a microdialysis study with freely moving rats.

Authors:  Y Aono; T Saigusa; S Watanabe; T Iwakami; N Mizoguchi; H Ikeda; K Ishige; K Tomiyama; Y Oi; K Ueda; W-D Rausch; J L Waddington; Y Ito; N Koshikawa; A R Cools
Journal:  J Neural Transm (Vienna)       Date:  2007-05-29       Impact factor: 3.575

8.  Alpha 2-adrenoceptor mediated inhibition of [3H]dopamine release from nucleus accumbens slices and monoamine levels in a rat model for attention-deficit hyperactivity disorder.

Authors:  A S de Villiers; V A Russell; T Sagvolden; A Searson; A Jaffer; J J Taljaard
Journal:  Neurochem Res       Date:  1995-04       Impact factor: 3.996
  8 in total

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