Literature DB >> 3814050

Sex differences in the effects of gonadectomy on amphetamine-induced rotational behavior in rats.

D M Camp, J B Becker, T E Robinson.   

Abstract

The effects of gonadectomy on amphetamine-induced rotational behavior were studied in male and female rats. Different systemic doses were used to produce equivalent brain concentrations of the drug in each group, thereby controlling for sex differences in the metabolism of amphetamine. Ovariectomy of female rats significantly attenuated amphetamine-induced rotation, whereas castration of males was without effect. The results support the idea that in females, the endogenous gonadal hormones facilitate functional activity in the mesostriatal dopamine system.

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Year:  1986        PMID： 3814050     DOI： 10.1016/s0163-1047(86)90527-3

Source DB:  PubMed          Journal:  Behav Neural Biol        ISSN： 0163-1047


  13 in total

1.  Interactions among ovarian hormones and time of testing on behavioral sensitization and cocaine self-administration.

Authors:  Hongyan Yang; Wei Zhao; Ming Hu; Jill B Becker
Journal:  Behav Brain Res       Date:  2007-07-12       Impact factor: 3.332

2.  The estrous cycle affects cocaine self-administration on a progressive ratio schedule in rats.

Authors:  D C Roberts; S A Bennett; G J Vickers
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

Review 3.  Sex differences, gender and addiction.

Authors:  Jill B Becker; Michele L McClellan; Beth Glover Reed
Journal:  J Neurosci Res       Date:  2017-01-02       Impact factor: 4.164

4.  Ovariectomy of adult rats leads to increased expression of astrocytic basic fibroblast growth factor in the ventral tegmental area and in dopaminergic projection regions of the entorhinal and prefrontal cortex.

Authors:  C Flores; N Salmaso; S Cain; D Rodaros; J Stewart
Journal:  J Neurosci       Date:  1999-10-01       Impact factor: 6.167

5.  Gonadectomy and hormone replacement affects in vivo basal extracellular dopamine levels in the prefrontal cortex but not motor cortex of adult male rats.

Authors:  T Aubele; M F Kritzer
Journal:  Cereb Cortex       Date:  2010-05-13       Impact factor: 5.357

6.  Androgens exacerbate motor asymmetry in male rats with unilateral 6-hydroxydopamine lesion.

Authors:  Rebecca L Cunningham; Teresa Macheda; Lora Talley Watts; Ethan Poteet; Meharvan Singh; James L Roberts; Andrea Giuffrida
Journal:  Horm Behav       Date:  2011-08-31       Impact factor: 3.587

7.  Androgen decreases dopamine neurone survival in rat midbrain.

Authors:  M L Johnson; A E Day; C C Ho; Q D Walker; R Francis; C M Kuhn
Journal:  J Neuroendocrinol       Date:  2010-01-27       Impact factor: 3.627

8.  Effects of sex and estrogen on behavioral sensitization to cocaine in rats.

Authors:  Ming Hu; Jill B Becker
Journal:  J Neurosci       Date:  2003-01-15       Impact factor: 6.167

9.  Gonadal steroids mediate the opposite changes in cocaine-induced locomotion across adolescence in male and female rats.

Authors:  Sarah L Parylak; Joseph M Caster; Q David Walker; Cynthia M Kuhn
Journal:  Pharmacol Biochem Behav       Date:  2008-01-16       Impact factor: 3.533

10.  Sex differences in the effects of cocaine abuse across the life span.

Authors:  Diana Dow-Edwards
Journal:  Physiol Behav       Date:  2010-01-01
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