Concentration of cefuroxime in the bones of albino white rats: a comparative study of femur, humerus, and mandible.

The levels of cefuroxime in rat bones with a different morphology, function, blood supply, and proportion between lamellar and cancellous bone were studied, after a 24-h administration of 750mg/kg X 3. The concentrations in the right and left femora, humeri, and mandibles of the same animal were measured 2 h after the last administration. The result indicate statistically significant differences between femur and humerus (P less than 0.001), femur and mandible (P less than 0.05), and humerus and mandible (P less than 0.05).